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Protein Page:
MAS1 (human)

Overview
MAS1 Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Receptor, GPCR; Oncoprotein; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q25.3-q26
Cellular Component: cell surface; integral to plasma membrane; intracellular; plasma membrane
Molecular Function: angiotensin receptor activity; angiotensin type II receptor activity; G-protein coupled receptor activity; peptide binding; peptide hormone binding; protein binding
Biological Process: activation of NF-kappaB-inducing kinase; anatomical structure morphogenesis; cell proliferation; G-protein coupled receptor protein signaling pathway; hippocampus development; male gonad development; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; positive regulation of DNA replication; regulation of inflammatory response; response to activity; response to drug; spermatogenesis
Reference #:  P04201 (UniProtKB)
Alt. Names/Synonyms: MAS; MAS1; MAS1 oncogene; MGC119966; Proto-oncogene Mas
Gene Symbols: MAS1
Molecular weight: 37,465 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Select Structure to View Below

MAS1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T104 LSSGHYYTIVTLSVT
0 1 T107 GHYYTIVTLSVTFLF
0 1 Y121‑p FGYNTGLyLLTAISV
0 1 Y227‑p ASHSSKLyIVIMVTI
  mouse

 
T103‑p LSSGHHYtIVtLSVT
T106‑p GHHYtIVtLSVTFLF
Y120 FGYNTGLYLLTAISV
Y226 ASHSSKLYIVIMVTI
  rat

 
T103 LSSGHYYTIVTLSVT
T106 GHYYTIVTLSVTFLF
Y120 FGYNTGLYLLTAISV
Y226 ASHSSKLYIVIMVTI
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