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Protein Page:
NPFFR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NPFFR1 Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10q21-q22
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: neuropeptide receptor activity; peptide binding
Biological Process: cellular response to hormone stimulus; synaptic transmission
Reference #:  Q9GZQ6 (UniProtKB)
Alt. Names/Synonyms: FLJ10751; G protein-coupled receptor 147; G-protein coupled receptor 147; GPR147; neuropeptide FF 1; Neuropeptide FF receptor 1; NPFF1; NPFF1R1; NPFFR1; OT7T022; RFamide-related peptide receptor OT7T022
Gene Symbols: NPFFR1
Molecular weight: 47,819 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
Select Structure to View Below

NPFFR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K152‑ac IVHPFREkLTLRKAL
0 1 Y216‑p EKGMRRVyTtVLFSH
0 1 T218‑p GMRRVyTtVLFSHIy
0 1 Y225‑p tVLFSHIyLAPLALI
0 1 Y236‑p LALIVVMyARIARKL
  mouse

 
K152 IVHPFREKLTLRKAL
Y216 EKGMRKVYTAVLFAH
A218 GMRKVYTAVLFAHIY
Y225 AVLFAHIYLAPLALI
Y236 LALIVVMYARIARKL
  rat

 
K152 IVHPFREKLTLRKAL
Y216 EKGMRKVYTAVLFAH
A218 GMRKVYTAVLFAHIY
Y225 AVLFAHIYLVPLALI
Y236 LALIVVMYVRIARKL
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