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Protein Page:
PIK3R4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3R4 Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Kinase, lipid; Kinase, protein; Other group; VPS15 family
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: axoneme; cytosol; late endosome; membrane; nuclear pore; phagocytic vesicle membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: cellular response to glucose starvation; late endosome to vacuole transport; macroautophagy; peroxisome degradation; phosphatidylinositol biosynthetic process; positive regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; protein targeting to vacuole; receptor catabolic process; regulation of cytokinesis; toll-like receptor 9 signaling pathway
Reference #:  Q99570 (UniProtKB)
Alt. Names/Synonyms: MGC102700; p150; phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3R4; PIK3R4; VPS15
Gene Symbols: PIK3R4
Molecular weight: 153,103 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  Autophagy Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3R4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T61‑p VFAIQDPtLPLTSYk
0 1 K68‑ub tLPLTSYkQELEELk
0 2 K75‑ub kQELEELkIRLNSAQ
0 2 K89‑ub QNCLPFQkASEKASE
0 3 K97‑ub ASEKASEkAAMLFRQ
0 1 S115‑p DNLYDRIstRPFLNN
0 1 T116‑p NLYDRIstRPFLNNI
0 1 K280‑ub FPEQVLNkIEDHSIR
0 1 K300 MIHREPDKRLEAEDY
0 2 K309‑ub LEAEDYLkQQRGNAF
0 1 S338‑p FAKETFLsADERILV
0 1 K449‑ub TKVLALVkEVPRNDI
0 1 T543 MVQQKVVTLLSDPEN
0 1 S546 QKVVTLLSDPENIVk
0 1 K553‑ub SDPENIVkQTLMENG
0 1 T555 PENIVkQTLMENGIT
0 1 N559 VkQTLMENGITRLCV
0 3 Y673‑p HPNLWIRyGAVGFIt
0 2 T680‑p yGAVGFItVVARQIS
0 1 K736‑ub FDYALRSkDITsLFR
0 1 S740‑p LRSkDITsLFRHLHM
0 1 K773‑ub AIAQLLKkLLSQGMt
0 1 T780‑p kLLSQGMtEEEEDKL
0 1 K791‑ub EDKLLALkDFMMKSN
0 1 S808‑p KANIVDQsHLHDssQ
0 5 S813‑p DQsHLHDssQKGVID
0 1 S814‑p QsHLHDssQKGVIDL
0 2 K850‑ub KRARKHVkQDsNVNE
0 7 S853‑p RKHVkQDsNVNEEWK
0 4 S861‑p NVNEEWKsMFGsLDP
0 11 S865‑p EWKsMFGsLDPPNMP
0 2 K888‑ub QEVIQTGkPPRsEsS
0 1 P889 EVIQTGkPPRsEsSA
0 1 S892‑p QTGkPPRsEsSAGIC
0 3 S894‑p GkPPRsEsSAGICVP
0 1 S895 kPPRsEsSAGICVPL
0 6 S905 ICVPLSTSSQVPEVT
0 1 K918‑ub VTTVQNKkPVIPVLs
0 2 S925‑p kPVIPVLsStILPST
0 1 T927‑p VIPVLsStILPSTYQ
0 1 T942‑p IRITTCKtELQQLIQ
0 2 K951‑ac LQQLIQQkREQCNAE
0 1 K951‑ub LQQLIQQkREQCNAE
0 1 S1022 GTVKIWNSQKMEGKT
0 1 S1074‑p QLLGIEAsKLPKsPK
0 3 S1079‑p EAsKLPKsPKIHPLQ
0 1 Y1272‑p IRFWDLAyPERSYVV
0 1 T1283‑p SYVVAGStSSPSVsy
0 1 S1289‑p StSSPSVsyyRkIIE
0 1 Y1290‑p tSSPSVsyyRkIIEG
0 2 Y1291‑p SSPSVsyyRkIIEGT
0 1 R1292 SPSVsyyRkIIEGTE
0 1 K1293‑ub PSVsyyRkIIEGTEV
0 1 K1307‑ub VVQEIQNkQKVGPSD
0 1 T1316‑p KVGPSDDtPRRGPES
  mouse

 
T61 VFAIQDPTLPLTSYK
K68 TLPLTSYKQELEELk
K75‑ub KQELEELkIRLHSAQ
K89‑ub QNCLPFQkAAEKASE
K97‑ub AAEKASEkAAMLFRQ
S115 DNLYDRISTRPFLNN
T116 NLYDRISTRPFLNNI
K280 FPEQVLNKIEDRSIR
K300‑ub MINREPEkRLEAEDY
K309‑ub LEAEDYLkQQRGNAF
S338 FAKETFLSADERILV
Q449 TKVLALVQEVPRNDV
T543‑p MVQQKVVtLLsDPEN
S546‑p QKVVtLLsDPENIVK
K553 sDPENIVKQtLMEsG
T555‑p PENIVKQtLMEsGIT
S559‑p VKQtLMEsGITRLCV
Y673 HPNLWIRYGAVGFIT
T680 YGAVGFITVVAHQIS
K736 FDYALRSKDIASLFR
S740 LRSKDIASLFRHLHM
K773 TIAQLLKKLLSQGMT
T780 KLLSQGMTEEEEDKL
K791 EDKLLALKDFMMKSN
S808 KANAVDQSHLHDsSQ
S813‑p DQSHLHDsSQKGVID
S814 QSHLHDsSQKGVIDL
K850‑ub KRARKHVkQDsNVNE
S853‑p RKHVkQDsNVNEEWK
S861‑p NVNEEWKsMFGsLEP
S865‑p EWKsMFGsLEPPNIP
K888 HEVVQPGKPPRSEss
P889 EVVQPGKPPRSEssA
S892 QPGKPPRSEssAGIC
S894‑p GKPPRSEssAGICVP
S895‑p KPPRSEssAGICVPL
S905‑p ICVPLSTsPQVSEAA
K918 AAHIPSKKPVIPVVS
S925 KPVIPVVSSTVLPST
T927 VIPVVSSTVLPSTYQ
T942 IRITTCKTELQQLIQ
K951‑ac LQQLIQQkREQCNAE
K951 LQQLIQQKREQCNAE
S1022‑p GTVKIWNsQKMEGKT
S1074 QLLGIEASKLPKsPK
S1079‑p EASKLPKsPKIHPLQ
S1272 IRFWDLVSPERSYVV
T1283 SYVVAGSTGSPSVSY
S1289 STGSPSVSYYkKIIE
Y1290 TGSPSVSYYkKIIEG
Y1291 GSPSVSYYkKIIEGT
K1292‑ub SPSVSYYkKIIEGTE
K1293 PSVSYYkKIIEGTEV
K1307 VVQEIQNKQKVGPSD
T1316 KVGPSDDTPRRGPES
  rat

 
T61 VFAIQDPTLPLTSYK
K68 TLPLTSYKQELEELK
K75 KQELEELKIRLHSAQ
K89 QNCLPFQKAAEKASE
K97 AAEKASEKAAMLFRQ
S115 DNLYDRISTRPFLNN
T116 NLYDRISTRPFLNNI
K280 FPEQVLNKIEDRSIR
Q300 MIQREPGQRLEADDY
K309 LEADDYLKQQRGNAF
S338 FAKETFLSADERILV
Q449 TKVLALVQEVPRNDV
T543 MVQQKVVTLLSDPEN
S546 QKVVTLLSDPENIVK
K553 SDPENIVKQTLMENG
T555 PENIVKQTLMENGIT
N559 VKQTLMENGITRLCV
Y673 HPNLWIRYGAVGFIT
T680 YGAVGFITVVAHQIS
K736 FDYALRSKDIASLFR
S740 LRSKDIASLFRHLHM
K773 AIAQLLKKLLSQGMT
T780 KLLSQGMTEEEEDKL
K791 EDKLLALKDFMMKSN
S808 KANAVDQSHLHDSSQ
S813 DQSHLHDSSQKGVID
S814 QSHLHDSSQKGVIDL
K850 KRARKHVKQDsNVNE
S853‑p RKHVKQDsNVNEEWK
S861 NVNEEWKSMFGSLEP
S865 EWKSMFGSLEPPNIP
K888 HEVVPTGKsPRSESS
S889‑p EVVPTGKsPRSESSA
S892 PTGKsPRSESSAGVC
S894 GKsPRSESSAGVCVP
S895 KsPRSESSAGVCVPL
S905‑p VCVPLSTsPQVSEAA
K918 AAHIPSKKPVIPVVS
S925 KPVIPVVSSTVLPST
T927 VIPVVSSTVLPSTYQ
T942 IRITTCKTELQQLIQ
K951 LQQLIQQKREQCNAE
K951 LQQLIQQKREQCNAE
S1022 GTVKIWNSQKMEGKT
S1074 QLLGIEASKLPKSPK
S1079 EASKLPKSPKIHPLQ
S1272 IRFWDLVSPERSYVV
T1283 SYVVAGSTGSPSVSY
S1289 STGSPSVSYYKKIIE
Y1290 TGSPSVSYYKKIIEG
Y1291 GSPSVSYYKKIIEGT
K1292 SPSVSYYKKIIEGTE
K1293 PSVSYYKKIIEGTEV
K1307 VVQEIQNKQKVGPSD
T1316 KVGPSDDTPRRGPES
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