Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
TBCK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TBCK Belongs to the protein kinase superfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; TBCK family
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: endomembrane system; intracellular
Molecular Function: GTPase activator activity; Rab GTPase binding
Biological Process: intracellular protein transport; regulation of vesicle fusion
Disease: Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies 3
Reference #:  Q8TEA7 (UniProtKB)
Alt. Names/Synonyms: HSPC302; MGC16169; TBC domain-containing protein kinase-like protein; TBC1 domain containing kinase; TBCK; TBCKL
Gene Symbols: TBCK
Molecular weight: 100,679 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below

TBCK

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S118‑p GIVHRALsPHNILLD
0 1 Y153‑p DVDFPIGyPSYLAPE
0 1 T169‑p IAQGIFKtTDHMPSK
0 1 K310 EDISQLCKDINNDYL
0 2 K343‑ub LEKELVNkEIIRSKP
0 1 T379 RSSLLDDTTVTLSLC
0 1 K461 YKKNQIWKEARVDIP
0 2 Y732‑p GGRSSAPyFSAECPD
0 1 T775 LIDLCELTVTGHFKT
0 1 T782 TVTGHFKTPSKKTKS
0 1 S784 TGHFKTPSKKTKSSK
0 25 S890‑p TGLLTIPsPQI____
  mouse

► Hide Isoforms
 
S118 GIVHRALSPHNILLD
Y153 DVDFPIGYPSYLAPE
T169 IAQGIPKTTDHVPSE
K310‑ub EDISDLCkDIDNDYL
K343‑ub LEKELINkEIIRSKP
T379‑p RSSLLDDtTVTLSLC
K461‑ub YKKNQIWkEARVDIP
Y732 VVRSSAPYFSAECTD
- gap
- gap
- gap
- gap
  TBCK iso3  
S118 GIVHRALSPHNILLD
Y153 DVDFPIGYPSYLAPE
T169 IAQGIPKTTDHVPSE
K310 EDISDLCKDIDNDYL
K343 LEKELINKEIIRSKP
T379 RSSLLDDTTVTLSLC
K461 YKKNQIWKEARVDIP
Y732 VVRSSAPYFSAECTD
T775‑p LIDLCELtVTGHFKt
T782‑p tVTGHFKtPtKKTKS
T784‑p TGHFKtPtKKTKSSK
S890‑p TGLLTVPsPQI____
  rat

 
S118 GIVHRALSPHNILLD
Y153 DVDFPIGYPSYLAPE
S169 IAQGIFKSTDHVPSE
K310 EDISDVCKDIDDDYL
K343 LEKELINKEIIRSKP
- gap
K427 YKKNQIWKEARVDIP
Y699 VRSSSAPYFSAECTD
T742 LIDLCELTVTGHFKT
T749 TVTGHFKTPTKKTKS
T751 TGHFKTPTKKTKSSK
S857‑p TGLLTVPsPQI____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.