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Protein Page:
RNASEL (human)

RNASEL a multifunctional enzyme that possesses protein kinase and endoribonuclease activity, Mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.26.-; Kinase, protein; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component: cytosol; mitochondrial matrix
Molecular Function: protein binding; RNA binding
Biological Process: defense response to virus; negative regulation of viral genome replication; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport
Disease: Prostate Cancer, Hereditary, 1
Reference #:  Q05823 (UniProtKB)
Alt. Names/Synonyms: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNase; DKFZp781D08126; interferon-induced 2-5A-dependent RNase; MGC104972; MGC133329; PRCA1; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RN5A; RNase L; RNASEL; RNS4
Gene Symbols: RNASEL
Molecular weight: 83,533 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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