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PhosphoSitePlus
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Protein Page:
PDZD3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDZD3 Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: apical part of cell; brush border; cytosol; subapical complex
Molecular Function: guanylate cyclase inhibitor activity; ion channel inhibitor activity; protein binding; protein C-terminus binding
Biological Process: cGMP-mediated signaling; ion transport; negative regulation of cGMP biosynthetic process; negative regulation of guanylate cyclase activity; receptor guanylyl cyclase signaling pathway; response to toxin; water transport
Reference #:  Q86UT5 (UniProtKB)
Gene Symbols: PDZD3
Molecular weight: 61,032 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Select Structure to View Below

PDZD3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K276 VNGVSVEKFTHNQLT
0 1 K347 GFLLREEKGLDGRPG
1 0 S395‑p LGHEETVsRIQGQGS
0 1 S418‑p PEADRFFsMVRLsPL
0 2 S423‑p FFsMVRLsPLLFLEN
0 1 S436‑p ENTEAPAsPRGSSSA
  mouse

 
K210‑ub VNGASVEkLTYNQLN
K281‑ub GFLLREEkGLDGRLG
S329 LGHEETVSRIRAQGS
S352 PEADRFFSMVRLSPL
S357 FFSMVRLSPLLFLEN
- gap
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