Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
FANCC (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FANCC DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: chromatin; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: DNA repair; germ cell development; myeloid cell homeostasis; nucleotide-excision repair; protein complex assembly; removal of superoxide radicals
Disease: Fanconi Anemia, Complementation Group C; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Reference #:  Q00597 (UniProtKB)
Alt. Names/Synonyms: bA80I15.1 (Fanconi anemia, complementation group C, protein); FA3; FAC; FACC; FANCC; Fanconi anemia group C protein; Fanconi anemia, complementation group C; FLJ14675; Protein FACC
Gene Symbols: FANCC
Molecular weight: 63,429 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Select Structure to View Below

FANCC

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5 ___MAQDSVDLSCDY
0 1 S57‑p EALKEMDsNTVIERF
0 1 D84 NPFILAYDESQKILI
0 1 K277‑ub RRIECFIkDSSLPQA
  mouse

► Hide Isoforms
 
S5‑p ___MAQEsADLASDC
S57 EILKEMDSDAILERF
D84 NPLILAYDESQKIVI
R278 RRMECCIRESFLPQA
  FANCC iso2  
S5 ___MAQESADLASDC
S57 EILKEMDSDAILERF
Y84‑p NPLIFSIyESQKIVI
R278 RRMECCIRESFLPQA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.