a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Activates Rho. Protein kinase A blocks Rho activation by phosphorylation of G-alpha(13). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12)
Molecular Function: D5 dopamine receptor binding; G-protein beta/gamma-subunit binding; GTPase activity; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity; signal transducer activity; type 1 angiotensin receptor binding
Biological Process: cell motility; G-protein signaling, adenylate cyclase activating pathway; phospholipase D activation; platelet activation; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; signal transduction