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Protein Page:
G-alpha 13 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
G-alpha 13 a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Activates Rho. Protein kinase A blocks Rho activation by phosphorylation of G-alpha(13). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes. Note: This description may include information from UniProtKB.
Protein type: G protein, heterotrimeric; G protein, heterotrimeric alpha G(12); G protein
Chromosomal Location of Human Ortholog: 17q24.3
Cellular Component: brush border membrane; cytoplasm; cytosol; focal adhesion; heterotrimeric G-protein complex; melanosome; membrane; nucleus; plasma membrane
Molecular Function: D5 dopamine receptor binding; G-protein beta/gamma-subunit binding; GTP binding; GTPase activity; metal ion binding; protein binding; signal transducer activity; type 1 angiotensin receptor binding
Biological Process: blood coagulation; cell differentiation; cell motility; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; in utero embryonic development; metabolic process; patterning of blood vessels; phospholipase D activation; platelet activation; regulation of cell migration; regulation of cell shape; Rho protein signal transduction; signal transduction
Reference #:  Q14344 (UniProtKB)
Alt. Names/Synonyms: G alpha-13; G-protein subunit alpha-13; G13; GNA13; guanine nucleotide binding protein (G protein), alpha 13; Guanine nucleotide-binding protein subunit alpha-13; MGC46138
Gene Symbols: GNA13
Molecular weight: 44,050 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Select Structure to View Below

G-alpha 13

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T203‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9‑p ADFLPSRsVLSVCFP
0 1 K36‑ub RKSKEIDkCLSREKt
0 2 T43‑p kCLSREKtyVKRLVK
0 1 Y44‑p CLSREKtyVKRLVKI
0 3 Y145 ETRVFLQYLPAIRAL
0 1 K175 FQLGESVKYFLDNLD
0 1 K183‑ub YFLDNLDkLGEPDYI
1 1 T203‑p ILLARRPtKGIHEYD
0 3 K214‑ub HEYDFEIkNVPFkMV
0 2 K219‑ub EIkNVPFkMVDVGGQ
0 1 S285‑p NRVFSNVsIILFLNK
0 2 K363‑ac RLVFRDVkDTILHDN
0 1 K372‑ac TILHDNLkQLMLQ__
0 7 K372‑ub TILHDNLkQLMLQ__
  mouse

 
S9 ADFLPSRSVLSVCFP
K36 RKSKEIDKCLSREKt
T43‑p KCLSREKtYVKRLVK
Y44 CLSREKtYVKRLVKI
Y145 ETRVFLQYLPAIRAL
K175‑ub FQLGESVkYFLDNLD
K183 YFLDNLDKLGVPDYI
T203 ILLARRPTKGIHEYD
K214‑ub HEYDFEIkNVPFkMV
K219‑ub EIkNVPFkMVDVGGQ
S285 NRVFSNVSIILFLNK
K363 RLVFRDVKDTILHDN
K372 TILHDNLKQLMLQ__
K372 TILHDNLKQLMLQ__
  rat

 
S9 ADFLPSRSVLSVCFP
K36 RKSKEIDKCLSREKT
T43 KCLSREKTYVKRLVK
Y44 CLSREKTYVKRLVKI
Y145‑p ETRVFLQyLPAIRAL
K175 FQLGESVKYFLDNLD
K183 YFLDNLDKLGVPDYI
T203 ILLARRPTKGIHEYD
K214 HEYDFEIKNVPFKMV
K219 EIKNVPFKMVDVGGQ
S285 NRVFSNVSIILFLNK
K363‑ac RLVFRDVkDTILHDN
K372 TILHDNLKQLMLQ__
K372 TILHDNLKQLMLQ__
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