a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Activates Rho. Protein kinase A blocks Rho activation by phosphorylation of G-alpha(13). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes. Note: This description may include information from UniProtKB.
Protein type: G protein, heterotrimeric alpha G(12); G protein; G protein, heterotrimeric
Molecular Function: D5 dopamine receptor binding; G-protein beta/gamma-subunit binding; GTP binding; GTPase activity; metal ion binding; protein binding; signal transducer activity; type 1 angiotensin receptor binding
Biological Process: blood coagulation; cell differentiation; cell motility; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; in utero embryonic development; metabolic process; patterning of blood vessels; phospholipase D activation; platelet activation; regulation of cell migration; regulation of cell shape; Rho protein signal transduction; signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.