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Protein Page:
IkB-beta (rat)

Overview
IkB-beta a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA- dependent inactivation. Association with inhibitor kappa B- interacting Ras-like proteins 1 and 2 may also explain the slower degradation. Interacts with ligand-binding domain of thyroid hormone receptor-beta, inhibitor kappa B-interacting Ras-like protein 1, inhibitor kappa B-interacting protein Ras2, p65 (RELA) and c-Rel. Expressed in all tissues examined. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: NF-kappaB binding
Biological Process: cytoplasmic sequestering of NF-kappaB; signal transduction
Reference #:  Q9JIA3 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-beta; IkappaBbeta; IkB-B; IkB-beta; Ikbb; MGC93398; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Gene Symbols: Nfkbib
Molecular weight: 38,081 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IkB-beta

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: Y161‑p
molecular association, regulation: Y161‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
5 0 S19‑p DADEWCDsGLGsLGP
5 0 S23‑p WCDsGLGsLGPDAAA
0 1 - gap
0 1 - gap
1 2 Y161‑p PRDASDTyLTQSQDH
0 3 P183 PVATDPQPNPGNEEE
0 1 T239 DLNKPEPTCGRTPLH
0 1 T276 ARMYGGRTPLGSALL
0 1 S280 GGRTPLGSALLRPNP
0 1 L308 PEDKDDKLSPCSNSS
3 0 N313 DKLSPCSNSSSDSDS
3 0 S318 CSNSSSDSDSDNRDE
0 8 S346‑p SQNQPPPsPAAKPLP
  human

► Hide Isoforms
 
S19‑p DADEWCDsGLGsLGP
S23‑p WCDsGLGsLGPDAAA
- gap
- gap
Y161‑p PREAPDTyLAQGPDR
S183‑p PVALYPDsDLEKEEE
T239‑p DLDKPEPtCGRSPLH
T276‑p ARMYGGRtPLGsAML
S280‑p GGRtPLGsAMLRPNP
S308‑p PEGEDEKsGPCSsSs
S313‑p EKsGPCSsSsDSDSG
S315‑p sGPCSsSsDSDSGDE
T343 SQTRLPPTPASKPLP
4921 : Phospho-IkappaB-beta (Thr19/Ser23) Antibody (Human Specific)
4921 : Phospho-IkappaB-beta (Thr19/Ser23) Antibody (Human Specific)
  IkB-beta iso3  
- gap
- gap
S36‑p RGCRGLPsSSATSLR
T46‑p ATSLRMGtRFSAGTE
Y129 PREAADTYLAQGPDR
S151 PVALYPDSDLEKEEE
T207 DLDKPEPTCGRSPLH
T244 VRMYGGRTPLGSAML
S248 GGRTPLGSAMLRPNP
S276 PEGEDEKSGPCSSSS
S281 EKSGPCSSSSDSDSG
S283 SGPCSSSSDSDSGDE
- gap
  mouse

 
S19‑p DADEWCDsGLGsLGP
S23‑p WCDsGLGsLGPDAAA
- gap
- gap
Y161 PRDASDTYLTQSQDC
P183 PAAVDSQPNPENEEE
T239 DLNKPEPTCGRTPLH
T276 ARMYGGRTPLGSALL
S280 GGRTPLGSALLRPNP
L308 PEDEDDKLSPCSSSG
S313 DKLSPCSSSGSDSDS
S318 CSSSGSDSDSDNRDE
S346‑p SQNRQPPsPASKPLP
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