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Protein Page:
FGB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGB Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGB are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Adaptor/scaffold; Secreted; Cell surface
Chromosomal Location of Human Ortholog: 4q28
Cellular Component: cell surface; external side of plasma membrane; extracellular region; extracellular space; fibrinogen complex; plasma membrane
Molecular Function: cell adhesion molecule binding; chaperone binding; protein binding; receptor binding; structural molecule activity
Biological Process: blood coagulation; cell-matrix adhesion; cellular protein complex assembly; extracellular matrix organization and biogenesis; fibrinolysis; induction of bacterial agglutination; plasminogen activation; platelet degranulation; positive regulation of exocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of protein secretion; positive regulation of vasoconstriction; protein polymerization; response to calcium ion
Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital
Reference #:  P02675 (UniProtKB)
Alt. Names/Synonyms: FGB; FIBB; Fibrinogen beta chain; fibrinogen, B beta polypeptide; fibrinogen, beta chain; Fibrinopeptide B; MGC104327; MGC120405
Gene Symbols: FGB
Molecular weight: 55,928 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Select Structure to View Below

FGB

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R53 HRPLDKKREEAPsLR
0 2 S58‑p KKREEAPsLRPAPPP
0 4 Y71‑p PPISGGGyRARPAKA
0 1 S138‑p NNNVEAVsQTSSSSF
0 1 Y172‑p NENVVNEyssELEKH
0 2 S173‑p ENVVNEyssELEKHQ
0 1 S174‑p NVVNEyssELEKHQL
1 1 Y182‑p ELEKHQLyIDETVNS
0 1 K208‑ac ILENLRSkIQKLESD
0 1 T228‑p EYCRTPCtVSCNIPV
0 1 S237‑p SCNIPVVsGKECEEI
0 1 K247 ECEEIIRKGGETSEM
0 1 Y255‑p GGETSEMyLIQPDss
0 1 S261‑p MyLIQPDssVKPyRV
0 1 S262‑p yLIQPDssVKPyRVy
0 1 K264 IQPDssVKPyRVyCD
0 5 Y266‑p PDssVKPyRVyCDMN
0 1 Y269‑p sVKPyRVyCDMNTEN
0 1 N273 yRVyCDMNTENGGWt
0 1 T280‑p NTENGGWtVIQNRQD
0 1 S289‑p IQNRQDGsVDFGRKW
0 1 Y299‑p FGRKWDPykQGFGNV
0 1 K300‑ac GRKWDPykQGFGNVA
0 4 K313‑ac VATNTDGkNyCGLPG
0 1 K313 VATNTDGKNyCGLPG
0 1 K313 VATNTDGKNyCGLPG
0 1 Y315‑p TNTDGkNyCGLPGEY
0 1 T333‑p NDKISQLtRMGPtEL
0 2 T338‑p QLtRMGPtELLIEME
0 2 K348‑ac LIEMEDWkGDKVKAH
0 1 K353 DWkGDKVKAHyGGFT
0 2 Y356‑p GDKVKAHyGGFTVQN
0 2 Y368‑p VQNEANKyQIsVNKY
0 1 S371‑p EANKyQIsVNKYRGT
0 1 K374 KyQIsVNKYRGTAGN
0 1 K374 KyQIsVNKYRGTAGN
0 1 T396‑p QLMGENRtMTIHNGM
0 1 Y408‑p NGMFFSTyDRDNDGW
0 1 K426 DPRKQCSKEDGGGWW
0 1 Y452‑p RYYWGGQyTWDMAKH
0 5 K471‑ac GVVWMNWkGSWySMR
0 1 Y475‑p MNWkGSWySMRKMSM
  mouse

 
K43‑ub HRPVDRRkEEPPSLR
S48 RRkEEPPSLRPAPPP
Y61 PPISGGGYRARPAKA
S128 NNNIQSVSDTSSVTF
Y162 NENVINEYSSILEDQ
S163 ENVINEYSSILEDQR
S164 NVINEYSSILEDQRL
Y172 ILEDQRLYIDETVND
K198 ILEDLRSKIQKLESD
T218 EYCRTPCTVSCNIPV
S227 SCNIPVVSGKECEEI
K237‑ub ECEEIIRkGGETSEM
Y245 GGETSEMYLIQPDTS
T251 MYLIQPDTSIkPYRV
S252 YLIQPDTSIkPYRVY
K254‑ub IQPDTSIkPYRVYCD
Y256 PDTSIkPYRVYCDMk
Y259 SIkPYRVYCDMkTEN
K263‑ub YRVYCDMkTENGGWT
T270 kTENGGWTVIQNRQD
S279 IQNRQDGSVDFGRKW
Y289 FGRKWDPYKKGFGNI
K290 GRKWDPYKKGFGNIA
K303‑ac IATNEDAkKYCGLPG
K303‑ub IATNEDAkKYCGLPG
K303‑sc IATNEDAkKYCGLPG
Y305 TNEDAkKYCGLPGEY
T323 NDKISQLTRMGPTEL
T328 QLTRMGPTELLIEME
K338 LIEMEDWKGDKVkAH
K343‑ub DWKGDKVkAHYGGFT
Y346 GDKVkAHYGGFTVQN
Y358 VQNEASKYQVSVNkY
S361 EASKYQVSVNkYKGT
K364 KYQVSVNKYKGTAGN
K364‑ub KYQVSVNkYKGTAGN
T386 QLVGENRTMTIHNGM
Y398 NGMFFSTYDRDNDGW
K416‑ub DPRKQCSkEDGGGWW
Y442 RYYWGGLYSWDMSKH
K461 GVVWMNWKGSWYSMR
Y465 MNWKGSWYSMRRMSM
  rat

 
K41 HRPVDRRKEEPPSLR
S46 RRKEEPPSLRPAPPP
Y59 PPISGGGYRARPAKV
S126 NSNINSVSETSSVTF
Y160 NENVINEYSSILEDQ
S161 ENVINEYSSILEDQK
S162 NVINEYSSILEDQKL
Y170 ILEDQKLYIDETVND
K196 ILEDLRSKIQKLESD
T216 EYCHTPCTVNCNIPV
S225 NCNIPVVSGKECEEI
K235 ECEEIIRKGGETSEM
Y243 GGETSEMYLIQPDTS
T249 MYLIQPDTSSKPYRV
S250 YLIQPDTSSKPYRVY
K252 IQPDTSSKPYRVYCD
Y254 PDTSSKPYRVYCDMK
Y257 SSKPYRVYCDMKTEN
K261 YRVYCDMKTENGGWT
T268 KTENGGWTVIQNRQD
S277 IQNRQDGSVDFGRKW
Y287 FGRKWDPYKKGFGNI
K288 GRKWDPYKKGFGNIA
K301 IATNEDTKKYCGLPG
K301 IATNEDTKKYCGLPG
K301 IATNEDTKKYCGLPG
Y303 TNEDTKKYCGLPGEY
T321 NDKISQLTRIGPTEL
T326 QLTRIGPTELLIEME
K336 LIEMEDWKGDKVKAH
K341 DWKGDKVKAHYGGFT
Y344 GDKVKAHYGGFTVQT
Y356 VQTEANKYQVSVNkY
S359 EANKYQVSVNkYKGT
K362‑ac KYQVSVNkYKGTAGN
K362 KYQVSVNKYKGTAGN
T384 QLVGENRTMTIHNGM
Y396 NGMFFSTYDRDNDGW
K414 DPRKQCSKEDGGGWW
Y440 RYYWGGLYSWDMSKH
K459 GVVWMNWKGSWYSMR
Y463 MNWKGSWYSMRRMSM
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