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Protein Page:
BCHE (human)

BCHE Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Nuclear envelope; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q26.1-q26.2
Cellular Component: extracellular region
Molecular Function: acetylcholinesterase activity; cholinesterase activity; hydrolase activity, acting on ester bonds
Biological Process: cocaine metabolic process
Reference #:  P06276 (UniProtKB)
Alt. Names/Synonyms: Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; butyrylcholinesterase; CHE1; CHLE; Choline esterase II; Cholinesterase; cholinesterase 1; E1; Pseudocholinesterase
Gene Symbols: BCHE
Molecular weight: 68,418 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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