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Protein Page:
SIX3 (mouse)

Overview
SIX3 May be involved in visual system development. Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the SIX/Sine oculis homeobox family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Cellular Component: nucleus
Molecular Function: DNA binding; histone deacetylase binding; protein binding; receptor binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity
Biological Process: brain development; camera-type eye development; cell proliferation in forebrain; circadian behavior; diencephalon development; epithelial cell maturation; eye development; forebrain anterior/posterior pattern formation; forebrain dorsal/ventral pattern formation; lens development in camera-type eye; multicellular organismal development; negative regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; neuroblast differentiation; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus; protein import into nucleus, translocation; proximal/distal axis specification; regulation of cell proliferation; regulation of transcription, DNA-dependent; telencephalon development; telencephalon regionalization; transcription, DNA-dependent
Reference #:  Q62233 (UniProtKB)
Gene Symbols: Six3
Molecular weight: 35,593 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below

SIX3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S26 FADSHHCSLLLASSG
0 1 G48 GGGGAGGGGGGNRAG
0 1 S66‑p AGGAGGGsGGGGSRA
0 1 Y150 TGNFRDLYHILENHK
0 1 T159 ILENHKFTKESHGKL
  human

 
S26‑p FADSHHRsILLASSG
S48‑p GGGAGGGsGGGNGAG
G65 GAGGAGGGGGGGSRA
Y149‑p TGNFRDLyHILENHK
T158‑p ILENHKFtKESHGKL
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