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Protein Page:
TRIO (human)

TRIO Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; CAMK group; EC; GEFs; GEFs, misc.; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family
Chromosomal Location of Human Ortholog: 5p15.2
Cellular Component: cytosol
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway
Disease: Mental Retardation, Autosomal Dominant 44
Reference #:  O75962 (UniProtKB)
Alt. Names/Synonyms: ARHGEF23; FLJ42780; PTPRF-interacting protein; tgat; TRIO; triple functional domain (PTPRF interacting); Triple functional domain protein
Gene Symbols: TRIO
Molecular weight: 346,900 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
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Protein Structure Not Found.
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