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BOK
May play a role in apoptosis. Belongs to the Bcl-2 family. Note: This description may include information from UniProtKB.
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| Chromosomal Location of Human Ortholog: 1|1 D |
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Cellular Component: cytoplasm; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane; mitochondrial inner membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nucleus; recycling endosome membrane; trans-Golgi network membrane
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Molecular Function: BH domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; receptor binding; ubiquitin protein ligase binding
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Biological Process: apoptosis; caspase activation; caspase activation via cytochrome c; cell structure disassembly during apoptosis; cytosolic calcium ion homeostasis; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of mitochondrial depolarization; negative regulation of neuron apoptosis; neuron apoptosis; positive regulation of apoptosis; protein oligomerization; regulation of autophagy; release of cytochrome c from mitochondria
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Reference #:
O35425
(UniProtKB)
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Alt. Names/Synonyms: AI847676; Apoptosis activator Mtd; AU021146; Bcl-2-related ovarian killer protein; Bcl-2-related ovarian killer protein-like; BCL2-related ovarian killer protein; Bok; matador; Mtd; Protein matador
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Gene Symbols: Bok
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Molecular weight:
23,456 Da
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Basal Isoelectric point:
9.33
Predict pI for various phosphorylation states
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