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Protein Page:
BMPR1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BMPR1A a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; EC 2.7.11.30; Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 10q22.3
Cellular Component: caveola; external side of plasma membrane; plasma membrane
Molecular Function: ATP binding; glycoprotein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; immune response; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway
Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
Reference #:  P36894 (UniProtKB)
Alt. Names/Synonyms: 10q23del; activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ACVRLK3; ALK-3; ALK3; BMP type-1A receptor; BMPR-1A; BMPR1A; BMPRIA; BMR1A; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
Gene Symbols: BMPR1A
Molecular weight: 60,198 Da
Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states
Select Structure to View Below

BMPR1A

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S19 GAYLFIISRVQGQNL
0 1 S205 AFIPVGESLKDLIDQ
0 1 K232 LVQRTIAKQIQMVRQ
0 1 Y407‑p TRVGTKRyMAPEVLD
1 0 Y453 TGGIVEEYQLPYYNM
1 0 Y457 VEEYQLPYYNMVPSD
1 0 Y458 EEYQLPYYNMVPSDP
1 0 Y467 MVPSDPSYEDMREVV
0 1 K523 RIKKTLAKMVESQDV
0 1 S527 TLAKMVESQDVkI__
0 2 K531‑ub MVESQDVkI______
  mouse

 
S19‑p GACLFIIsHVQGQNL
S205 AFIPVGESLKDLIDQ
K232‑ub LVQRTIAkQIQMVRQ
Y407 TRVGTKRYMAPEVLD
Y453‑p TGGIVEEyQLPyyNM
Y457‑p VEEyQLPyyNMVPSD
Y458‑p EEyQLPyyNMVPSDP
Y467‑p MVPSDPSyEDMREVV
K523‑ub RIKKTLAkMVEsQDV
S527‑p TLAkMVEsQDVKI__
K531 MVEsQDVKI______
  rat

 
S19 GACLFIISHVQGQNL
S205‑p AFIPVGEsLKDLIDQ
K232 LVQRTIAKQIQMVRQ
Y407 TRVGTRRYMAPEVLD
Y453 TGGIVEEYQLPYYNM
Y457 VEEYQLPYYNMVPSD
Y458 EEYQLPYYNMVPSDP
Y467 MVPSDPSYEDMREVV
K523 RIKKTLAKMVESQDV
S527 TLAKMVESQDVKI__
K531 MVESQDVKI______
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