a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; EC 220.127.116.11; Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; TKL group; STKR family; Type1 subfamily
Cellular Component: caveola; external side of plasma membrane; plasma membrane
Molecular Function: ATP binding; glycoprotein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; immune response; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.