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Protein Page:
BMPR1A (human)

BMPR1A a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily
Chromosomal Location of Human Ortholog: 10q22.3
Cellular Component: caveola; external side of plasma membrane; plasma membrane
Molecular Function: ATP binding; glycoprotein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; immune response; negative regulation of smooth muscle cell migration; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway
Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
Reference #:  P36894 (UniProtKB)
Alt. Names/Synonyms: 10q23del; activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ACVRLK3; ALK-3; ALK3; BMP type-1A receptor; BMPR-1A; BMPR1A; BMPRIA; BMR1A; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
Gene Symbols: BMPR1A
Molecular weight: 60,198 Da
Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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