Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, integral
Cellular Component: cytosol; endoplasmic reticulum; integral to mitochondrial outer membrane; integral to peroxisomal membrane; membrane; mitochondrion; peroxisome; protein complex
Molecular Function: protein binding; receptor binding
Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; mitochondrion degradation; peroxisome fission; positive regulation of caspase activity; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.