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Protein Page:
SQLE (human)

Overview
SQLE Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Belongs to the squalene monooxygenase family. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.13.132; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 8q24.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: squalene monooxygenase activity
Biological Process: cholesterol biosynthetic process
Reference #:  Q14534 (UniProtKB)
Alt. Names/Synonyms: ERG1; FLJ30795; SE; SQLE; Squalene epoxidase; Squalene monooxygenase
Gene Symbols: SQLE
Molecular weight: 63,923 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
Select Structure to View Below

SQLE

Protein Structure Not Found.


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