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Protein Page:
SQLE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SQLE Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Belongs to the squalene monooxygenase family. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.13.132; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 8q24.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: squalene monooxygenase activity
Biological Process: cholesterol biosynthetic process
Reference #:  Q14534 (UniProtKB)
Alt. Names/Synonyms: ERG1; FLJ30795; SE; SQLE; Squalene epoxidase; Squalene monooxygenase
Gene Symbols: SQLE
Molecular weight: 63,923 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
Select Structure to View Below

SQLE

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 K90‑ub SPPESENkEQLEARR
0 1 T150‑p SRDGRKVtVIERDLK
0 3 K290‑ub VADGLFSkFRKSLVS
0 1 K312‑ub HFVGFLMkNAPQFKA
0 1 K426 GGMTVAFKDIKLWRk
0 2 K426‑ub GGMTVAFkDIKLWRk
0 2 K433‑ub kDIKLWRkLLkGIPD
0 8 K436‑ub KLWRkLLkGIPDLYD
0 1 K451 DAAIFEAKKSFYWAR
0 1 K452 AAIFEAKKSFYWARK
0 2 K556‑ub SSGAVLYkACsVIFP
0 1 S559‑p AVLYkACsVIFPLIy
0 1 Y566‑p sVIFPLIysEMKYMV
0 1 S567‑p VIFPLIysEMKYMVH
  mouse

 
K88 KSPESEKKEQLESKK
T148 SRDGRKVTVIERDLK
K288‑ub VADGLFSkFRKSLIS
K310 HFVGFLMKDAPQFKP
K424‑ac GGMTVALkDIKLWRQ
K424‑ub GGMTVALkDIKLWRQ
Q431 kDIKLWRQLLkDIPD
K434‑ub KLWRQLLkDIPDLYD
K449‑ub DAAIFQAkkSFFWSR
K450‑ub AAIFQAkkSFFWSRK
K554 SSGAVLYKACSILFP
S557 AVLYKACSILFPLIY
Y564 SILFPLIYSEMKYLV
S565 ILFPLIYSEMKYLVH
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