a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Membrane protein, integral; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Trk family
Cellular Component: axon; cell soma; cell surface; cytoplasm; cytosol; dendrite; dendritic spine; endosome; excitatory synapse; growth cone; integral to membrane; integral to plasma membrane; membrane; nerve terminal; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; receptor complex; rough endoplasmic reticulum; terminal button
Molecular Function: ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor receptor activity; kinase activity; neurotrophin binding; neurotrophin receptor activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein-tyrosine kinase activity; receptor tyrosine kinase binding; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: brain-derived neurotrophic factor receptor signaling pathway; cell differentiation; central nervous system neuron development; cerebral cortex development; feeding behavior; glutamate secretion; learning; long-term memory; mechanoreceptor differentiation; multicellular organismal development; negative regulation of neuron apoptosis; nervous system development; neuromuscular junction development; neuron differentiation; neuron migration; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system neuron development; phosphorylation; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite development; regulation of GTPase activity; regulation of MAPKKK cascade; regulation of metabolic process; regulation of neurotransmitter secretion; regulation of protein kinase B signaling cascade; retina development in camera-type eye; retinal rod cell development; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.