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Protein Page:
NPEPPS (human)

NPEPPS Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. Belongs to the peptidase M1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytosol; plasma membrane
Molecular Function: aminopeptidase activity; peptide binding; zinc ion binding
Biological Process: peptide catabolic process; protein polyubiquitination
Reference #:  P55786 (UniProtKB)
Alt. Names/Synonyms: AAP-S; AAPS; aminopeptidase puromycin sensitive; metalloproteinase MP100; MP100; NPEPPS; PSA; Puromycin-sensitive aminopeptidase
Gene Symbols: NPEPPS
Molecular weight: 103,276 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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