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Protein Page:
NR2F2 (human)

NR2F2 Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor
Chromosomal Location of Human Ortholog: 15q26
Cellular Component: nucleus
Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity
Biological Process: lipid metabolic process; negative regulation of cyclin-dependent protein kinase activity; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; signal transduction
Disease: Congenital Heart Defects, Multiple Types, 4
Reference #:  P24468 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor related protein 1; Apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ARP-1; ARP1; chicken ovalbumin upstream promoter transcription factor 2; COT2; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPTFB; COUPTFII; MGC117452; NR2F2; Nuclear receptor subfamily 2 group F member 2; nuclear receptor subfamily 2, group F, member 2; SVP40; TFCOUP2
Gene Symbols: NR2F2
Molecular weight: 45,571 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
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