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Protein Page:
GLRA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLRA3 The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, ion channel; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q34.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: extracellular-glycine-gated chloride channel activity; glycine binding; glycine-gated chloride ion channel activity
Biological Process: neuropeptide signaling pathway; protein homooligomerization; response to amino acid stimulus; synaptic transmission, glycinergic
Reference #:  O75311 (UniProtKB)
Alt. Names/Synonyms: GLRA3; glycine receptor alpha 3 subunit; Glycine receptor subunit alpha-3; glycine receptor, alpha 3; glycine receptor, alpha-3 polypeptide; ligand gated ion channel
Gene Symbols: GLRA3
Molecular weight: 53,800 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
Select Structure to View Below

GLRA3

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y57‑p LMGRTSGyDARIRPN
0 1 K223‑sm TLPQFLLkEEKDLRY
0 2 T358‑p RRKRKNKtEAFALEK
0 1 S370 LEKFYRFSDMDDEVR
2 0 S379 MDDEVRESRFsFTAY
0 1 S382‑p EVRESRFsFTAYGMG
  mouse

 
Y57 LMGRTSGYDARIRPN
K223 TLPQFLLKEEKDLRY
T358 RRKRKNKTEAFALEK
S370‑p LEKFYRFsDTDDEVR
S379‑p TDDEVREsRFSFTAY
S382 EVREsRFSFTAYGMG
  rat

 
Y57 LMGRTSGYDARIRPN
K223 TLPQFLLKEEKDLRY
T358 RRKRKNKTEAFALEK
S370 LEKFYRFSDTDDEVR
S379‑p TDDEVREsRLSFTAY
S382 EVREsRLSFTAYGMG
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