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Protein Page:
GLRA3 (human)

GLRA3 The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 4q34.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: extracellular-glycine-gated chloride channel activity; glycine binding; glycine-gated chloride ion channel activity
Biological Process: neuropeptide signaling pathway; protein homooligomerization; response to amino acid stimulus; synaptic transmission, glycinergic
Reference #:  O75311 (UniProtKB)
Alt. Names/Synonyms: GLRA3; glycine receptor alpha 3 subunit; Glycine receptor subunit alpha-3; glycine receptor, alpha 3; glycine receptor, alpha-3 polypeptide; ligand gated ion channel
Gene Symbols: GLRA3
Molecular weight: 53,800 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
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