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Protein Page:
PFKFB4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PFKFB4 Synthesis and degradation of fructose 2,6-bisphosphate. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Motility/polarity/chemotaxis; Kinase, other; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 3p22-p21
Cellular Component: cytosol
Molecular Function: 6-phosphofructo-2-kinase activity
Reference #:  Q16877 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; bifunctional enzyme with kinase and biphosphatase activities; F264; Fructose-2,6-bisphosphatase; PFK/FBPase 4; PFKFB4
Gene Symbols: PFKFB4
Molecular weight: 54,040 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below

PFKFB4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3‑p _____MAsPRELTQN
0 1 S119‑p RDVRRFLsEEGGHVA
0 3 S176 IVQVKLGSPDYVNRD
0 1 S214‑p EDLDRDLsYIKIMDV
0 3 K265‑ub GESELNLkGRIGGDP
0 1 S275‑p IGGDPGLsPRGREFA
0 1 R277 GDPGLsPRGREFAKS
0 1 R279 PGLsPRGREFAKSLA
0 1 K305‑ub KVWTSQMkRTIQTAE
  mouse

 
S3 _____MASPRELTQN
S119 SDVRKFLSEEGGHVA
S176‑p IVQVKLGsPDYVNRD
S214 EDLDRDLSYIKIMDV
K265 GESELNLKGRIGGDP
S275 IGGDPGLSPrGrEFS
R277‑m1 GDPGLSPrGrEFSKH
R279‑m1 PGLSPrGrEFSKHLA
K305 KVWTSQMKRTIQTAE
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