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Protein Page:
PSPH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSPH Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. Belongs to the SerB family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Hydrolase; EC 3.1.3.3; Amino Acid Metabolism - glycine, serine and threonine
Chromosomal Location of Human Ortholog: 7p11.2
Cellular Component: cytoplasm; cytosol
Molecular Function: calcium ion binding; magnesium ion binding; phosphoserine phosphatase activity; protein homodimerization activity
Biological Process: L-serine biosynthetic process; L-serine metabolic process
Disease: Phosphoserine Phosphatase Deficiency
Reference #:  P78330 (UniProtKB)
Alt. Names/Synonyms: L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; Phosphoserine phosphatase; PSP; PSPase; PSPH; SERB
Gene Symbols: PSPH
Molecular weight: 25,008 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Select Structure to View Below

PSPH

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S3 _____MVSHSELRKL
0 1 T88‑p AEQPPHLtPGIRELV
0 1 K158‑ub PTAESGGkGKVIKLL
0 1 K168 VIKLLKEKFHFKKII
0 1 K210 QQVKDNAKWYITDFV
  mouse

 
S3‑p _____MVsHSELRKL
T88 AEHPPHLTPGIRELV
K158 PTAESGGKGKVIRFL
K168 VIRFLKEKFHFKKII
K210‑ub QQVKDNAkWYITDFV
  rat

 
S3 _____MVSHSELRKL
T88 AEHPPHLTPGIRELV
K158 PTAESGGKGKVIGFL
K168‑ac VIGFLKEkFHFKKII
K210 QQVKDNAKWYITDFV
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