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Protein Page:
FGG (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGG Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q28
Cellular Component: cell cortex; cell surface; external side of plasma membrane; extracellular region; extracellular space; fibrinogen complex; plasma membrane
Molecular Function: cell adhesion molecule binding; metal ion binding; protein binding, bridging; receptor binding; structural molecule activity
Biological Process: blood coagulation; cell-matrix adhesion; cellular protein complex assembly; extracellular matrix organization and biogenesis; fibrinolysis; plasminogen activation; platelet activation; platelet degranulation; positive regulation of exocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of protein secretion; positive regulation of vasoconstriction; protein polymerization; protein secretion; response to calcium ion; signal transduction
Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital
Reference #:  P02679 (UniProtKB)
Alt. Names/Synonyms: FGG; FIBG; Fibrinogen gamma chain; fibrinogen, gamma chain; fibrinogen, gamma polypeptide
Gene Symbols: FGG
Molecular weight: 51,512 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
Select Structure to View Below

FGG

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y44‑p LDERFGSyCPTTCGI
0 1 Y58‑p IADFLSTyQTKVDKD
0 1 K84 ENKTSEVKQLIKAIQ
0 1 K84 ENKTSEVKQLIKAIQ
0 1 Y94‑p IKAIQLTyNPDESSK
0 1 K101 yNPDESSKPNMIDAA
0 17 Y140‑p IRYLQEIyNSNNQKI
0 1 K146 IyNSNNQKIVNLKEK
0 1 K185 DCQDIANKGAKQSGL
0 1 K196‑ac QSGLYFIkPLKANQQ
0 8 K231‑ac LDGSVDFkkNWIQYK
0 1 K232‑ac DGSVDFkkNWIQYKE
0 1 K232 DGSVDFkKNWIQYKE
0 1 E277 YALRVELEDWNGRTS
0 3 Y288‑p GRTSTADyAMFKVGP
0 12 Y300‑p VGPEADKyRLTYAYF
0 14 Y374‑p AGHLNGVyyQGGtyS
0 3 Y375‑p GHLNGVyyQGGtySk
0 2 T379‑p GVyyQGGtySkASTP
0 4 Y380‑p VyyQGGtySkASTPN
0 1 K382‑ac yQGGtySkASTPNGY
0 1 K399‑ac GIIWATWkTRWYSMk
0 1 K406‑ac kTRWYSMkKTTMKII
0 1 K406 kTRWYSMKKTTMKII
0 1 A431 QQHHLGGAKQVRPEH
0 1 R435 LGGAKQVRPEHPAET
0 1 Y444 EHPAETEYDSLYPED
  FGG iso2  
Y44 LDERFGSYCPTTCGI
Y58 IADFLSTYQTKVDKD
K84 ENKTSEVKQLIKAIQ
K84 ENKTSEVKQLIKAIQ
Y94 IKAIQLTYNPDESSK
K101 YNPDESSKPNMIDAA
Y140 IRYLQEIYNSNNQKI
K146 IYNSNNQKIVNLKEK
K185 DCQDIANKGAKQSGL
K196 QSGLYFIKPLKANQQ
K231 LDGSVDFKKNWIQYK
K232 DGSVDFKKNWIQYKE
K232 DGSVDFKKNWIQYKE
E277 YALRVELEDWNGRTS
Y288 GRTSTADYAMFKVGP
Y300 VGPEADKYRLTYAYF
Y374 AGHLNGVYYQGGTYS
Y375 GHLNGVYYQGGTYSK
T379 GVYYQGGTYSKASTP
Y380 VYYQGGTYSKASTPN
K382 YQGGTYSKASTPNGY
K399 GIIWATWKTRWYSMK
K406 KTRWYSMKKTTMKII
K406 KTRWYSMKKTTMKII
A431 QQHHLGGAKQAGDV_
G435 LGGAKQAGDV_____
- gap
  mouse

 
F43 LDERFGSFCPTTCGI
Y57 IADFLSSYQTDVDND
K83 ENRTTEAKELIKAIQ
K83‑ub ENRTTEAkELIKAIQ
Y93 IKAIQVYYNPDQPPk
K100‑ub YNPDQPPkPGMIDSA
Y139 IRYLQEIYNSNNQkI
K145‑ub IYNSNNQkITNLKQK
K184‑ub DCQEIANkGAKESGL
R195 ESGLYFIRPLKAKQQ
K230 IDGSLDFKkNWIQYK
K231 DGSLDFKKNWIQYKE
K231‑ub DGSLDFKkNWIQYKE
K276‑sc YALRIQLkDWNGRTS
Y287 GRTSTADYAMFRVGP
Y299 VGPESDKYRLTYAYF
Y373 AGHLNGVYHQGGTYS
H374 GHLNGVYHQGGTYSK
T378 GVYHQGGTYSKSSTT
Y379 VYHQGGTYSKSSTTN
K381 HQGGTYSKSSTTNGF
K398 GIIWATWKSRWYSMk
K405 KSRWYSMKETTMKII
K405‑sc KSRWYSMkETTMKII
S430 QQHHMGGSKQAGDV_
G434 MGGSKQAGDV_____
- gap
  rat

 
Y44 LDERFGSYCPTTCGI
Y58 ISDFLNSYQTDVDTD
K84‑ac ENRTTEAkELIKAIQ
K84 ENRTTEAKELIKAIQ
Y94 IKAIQVYYNPDQPPK
K101 YNPDQPPKPGMIEGA
Y140 IRYLQDIYTSNKQKI
K146 IYTSNKQKITNLKQK
K185 DCQDIANKGAKESGL
R196 ESGLYFIRPLKATQQ
K231 LDGSVDFKKNWIQYK
K232 DGSVDFKKNWIQYKE
K232 DGSVDFKKNWIQYKE
K277 YALRIQLKDWSGRTS
Y288 GRTSTADYAMFRVGP
Y300 VGPESDKYRLTYAYF
Y374 AGHLNGVYYQGGTYS
Y375 GHLNGVYYQGGTYSK
T379 GVYYQGGTYSKSSTP
Y380 VYYQGGTYSKSSTPN
K382 YQGGTYSKSSTPNGY
K399 GIIWATWKTRWYSMK
K406 KTRWYSMKETTMKII
K406 KTRWYSMKETTMKII
S431‑p QQHHMGGsKQVsVEH
S435‑p MGGsKQVsVEHEVDV
Y444‑p EHEVDVEyP______
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