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Protein Page:
EphB4 (human)

EphB4 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: cytosol; extracellular region; integral to plasma membrane; plasma membrane
Molecular Function: ephrin receptor activity; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: angiogenesis; cell adhesion; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; heart morphogenesis; protein amino acid autophosphorylation
Reference #:  P54760 (UniProtKB)
Alt. Names/Synonyms: EPH receptor B4; EPHB4; ephrin receptor EphB4; Ephrin type-B receptor 4; hepatoma transmembrane kinase; HTK; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11
Gene Symbols: EPHB4
Molecular weight: 108,270 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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