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Protein Page:
PGAM2 (human)

PGAM2 Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC (synthase) and EC (phosphatase), but with a reduced activity. Defects in PGAM2 are the cause of glycogen storage disease type 10 (GSD10). A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps and excercise intolerance. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC; EC; EC; Isomerase; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 7p13-p12
Cellular Component: cytosol; nucleus
Molecular Function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; phosphoglycerate mutase activity
Biological Process: gluconeogenesis; glycolysis; regulation of pentose-phosphate shunt; striated muscle contraction
Disease: Glycogen Storage Disease X
Reference #:  P15259 (UniProtKB)
Alt. Names/Synonyms: BPG-dependent PGAM 2; GSD10; MGC88743; Muscle-specific phosphoglycerate mutase; PGAM-M; PGAM2; PGAMM; Phosphoglycerate mutase 2; phosphoglycerate mutase 2 (muscle); Phosphoglycerate mutase isozyme M
Gene Symbols: PGAM2
Molecular weight: 28,766 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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