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Protein Page:
EphA5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EphA5 Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Eph family
Chromosomal Location of Human Ortholog: 4q13.1
Cellular Component: cell soma; dendrite; external side of plasma membrane; perinuclear region of cytoplasm; plasma membrane; rough endoplasmic reticulum
Molecular Function: ephrin receptor activity; GPI-linked ephrin receptor activity
Biological Process: activation of CREB transcription factor; axon guidance; cAMP-mediated signaling; ephrin receptor signaling pathway; hippocampus development; neuron development; regulation of actin cytoskeleton organization and biogenesis; regulation of GTPase activity
Reference #:  P54756 (UniProtKB)
Alt. Names/Synonyms: CEK7; EHK-1; EHK1; EK7; EPH homology kinase 1; Eph homology kinase-1; EPH receptor A5; EPH-like kinase 7; EPHA5; ephrin receptor EphA5; Ephrin type-A receptor 5; HEK7; receptor protein-tyrosine kinase HEK7; TYRO4; tyrosine-protein kinase receptor EHK-1
Gene Symbols: EPHA5
Molecular weight: 114,803 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EphA5

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S4‑p ____MRGsGPRGAGR
0 1 T197‑p DRVMKLNtEVRDVGP
0 2 Y295‑p KCMCKAGyEEKNGtC
0 1 T301‑p GyEEKNGtCQVCRPG
0 1 S313‑p RPGFFKAsPHIQsCG
0 1 S318‑p KAsPHIQsCGKCPPH
0 3 K387‑ub PADTGGRkDVSYYIA
0 1 Y391 GGRkDVSYYIACKKC
0 2 T649‑p IKLPGVRtyIDPHty
0 23 Y650‑p KLPGVRtyIDPHtyE
0 1 T655‑p RtyIDPHtyEDPNQA
0 26 Y656‑p tyIDPHtyEDPNQAV
0 1 S673‑p FAKEIEAsCItIERV
0 1 T676‑p EIEAsCItIERVIGA
0 3 K710‑ub PVAIKTLkVGYTEKQ
0 1 S746 LEGVVTKSKPVMIVT
0 1 S760 TEYMENGSLDTFLKK
0 1 T763 MENGSLDTFLKKNDG
0 1 Y790‑p GISAGMKyLSDMGYV
0 2 S822‑p KVSDFGLsRVLEDDP
1 715 Y833‑p EDDPEAAyTtRGGKI
0 2 T834 DDPEAAyTtRGGKIP
0 2 T835‑p DPEAAyTtRGGKIPI
0 1 T856‑p AIAFRKFtSASDVWS
0 1 S873‑p IVMWEVVsYGERPYW
0 1 S953‑p VNASCRVsNLLAEHs
0 1 S960‑p sNLLAEHsPLGsGAy
0 2 S964‑p AEHsPLGsGAyRSVG
0 3 Y967‑p sPLGsGAyRSVGEWL
8793 : EphA3/A4/A5 (D2C11) Rabbit mAb
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
  EphA5 iso2  
S4 ____MRGSGPRGAGR
T197 DRVMKLNTEVRDVGP
Y295 KCMCKAGYEEKNGTC
T301 GYEEKNGTCQVCRPG
S313 RPGFFKASPHIQSCG
S318 KASPHIQSCGKCPPH
K387 PADTGGRKDVSYYIA
Y391 GGRKDVSYYIACKKC
T627 IKLPGVRTYIDPHTY
Y628 KLPGVRTYIDPHTYE
T633 RTYIDPHTYEDPNQA
Y634 TYIDPHTYEDPNQAV
S651 FAKEIEASCITIERV
T654 EIEASCITIERVIGA
K688 PVAIKTLKVGYTEKQ
S724 LEGVVTKSKPVMIVT
S738 TEYMENGSLDTFLKK
T741 MENGSLDTFLKKNDG
Y768 GISAGMKYLSDMGYV
S800 KVSDFGLSRVLEDDP
Y811 EDDPEAAYTTRGGKI
T812 DDPEAAYTTRGGKIP
T813 DPEAAYTTRGGKIPI
T834 AIAFRKFTSASDVWS
S851 IVMWEVVSYGERPYW
S931 VNASCRVSNLLAEHS
S938 SNLLAEHSPLGSGAY
S942 AEHSPLGSGAYRSVG
Y945 SPLGSGAYRSVGEWL
  EphA5 iso3  
- gap
T128 DRVMKLNTEVRDVGP
Y226 KCMCKAGYEEKNGTC
T232 GYEEKNGTCQVCRPG
S244 RPGFFKASPHIQSCG
S249 KASPHIQSCGKCPPH
K318 PADTGGRKDVSYYIA
Y322 GGRKDVSYYIACKKC
T581 IKLPGVRTYIDPHTY
Y582 KLPGVRTYIDPHTYE
T587 RTYIDPHTYEDPNQA
Y588 TYIDPHTYEDPNQAV
S605 FAKEIEASCITIERV
T608 EIEASCITIERVIGA
K642 PVAIKTLKVGYTEKQ
S678 LEGVVTKSKPVMIVT
S692 TEYMENGSLDTFLKK
T695 MENGSLDTFLKKNDG
Y722 GISAGMKYLSDMGYV
S754 KVSDFGLSRVLEDDP
Y765 EDDPEAAYTTRGGKI
T766 DDPEAAYTTRGGKIP
T767 DPEAAYTTRGGKIPI
T788 AIAFRKFTSASDVWS
S805 IVMWEVVSYGERPYW
S885 VNASCRVSNLLAEHS
S892 SNLLAEHSPLGSGAY
S896 AEHSPLGSGAYRSVG
Y899 SPLGSGAYRSVGEWL
  mouse

 
S4 ____MRGSGPRGAGH
T199 DRVMKLNTEVRDVGP
Y297 KCMCKAGYEEKNGTC
T303 GYEEKNGTCQAPSPV
- gap
- gap
- gap
- gap
T488 IKLPGVRTyIDPHTy
Y489‑p KLPGVRTyIDPHTyE
T494 RTyIDPHTyEDPNQA
Y495‑p TyIDPHTyEDPNQAV
S512 FAKEIEASCITIERV
T515 EIEASCITIERVIGA
K549 PVAIKTLKVGYTEKQ
S585‑p LEGVVTKsKPVMIVT
S599‑p TEYMENGsLDtFLKK
T602‑p MENGsLDtFLKKNDG
Y629 GIAAGMKYLSDMGYV
S661‑p KVSDFGLsRVLEDDP
Y672‑p EDDPEAAyttRGGKI
T673‑p DDPEAAyttRGGKIP
T674‑p DPEAAyttRGGKIPI
T695 AIAFRKFTSSSDVWS
S712 IVMWEVVSYGERPYW
S792 VNASSRVSTLLAEHG
G799 STLLAEHGSLGSGAY
S803 AEHGSLGSGAYRSVG
Y806 GSLGSGAYRSVGEWL
8793 : EphA3/A4/A5 (D2C11) Rabbit mAb
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
  rat

 
S4 ____MRGSGPRGAGR
T199 DRVMKLNTEVRDVGP
Y297 KCMCKAGYEEKNGTC
T303 GYEEKNGTCQVCRPG
S315 RPGFFKASPHSQTCS
T320 KASPHSQTCSKCPPH
K389 PADTGGGKDVSyYIL
Y393‑p GGGKDVSyYILCKKC
T651 IKLPGVRTyIDPHTy
Y652‑p KLPGVRTyIDPHTyE
T657 RTyIDPHTyEDPTQA
Y658‑p TyIDPHTyEDPTQAV
S675 FGKEIEASCITIERV
T678 EIEASCITIERVIGA
K712 PVATKTLKVGYTEKQ
S748 LEGVVTKSKPVMIVT
S762 TEYMENGSLDTFLKK
T765 MENGSLDTFLKKNDG
Y792 GIAAGMKYLSDMGYV
S824 KVSDFGLSRVLEDDP
Y835‑p EDDPEAAyTTRGGKI
T836 DDPEAAyTTRGGKIP
T837 DPEAAyTTRGGKIPI
T858 AIAFRKFTSASDVWS
S875 IVMWEVVSYGERPYW
S955 VNASSRVSTLLAEHG
G962 STLLAEHGSLGSGAY
S966 AEHGSLGSGAYRSVG
Y969 GSLGSGAYRSVGEWL
8793 : EphA3/A4/A5 (D2C11) Rabbit mAb
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
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