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Protein Page:
GABRA3 (human)

Overview
GABRA3 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: benzodiazepine receptor activity; GABA-A receptor activity; protein binding
Biological Process: transport
Reference #:  P34903 (UniProtKB)
Alt. Names/Synonyms: GABA(A) receptor subunit alpha-3; GABRA3; gamma-aminobutyric acid (GABA) A receptor, alpha 3; Gamma-aminobutyric acid receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alpha 3; GBRA3; MGC33793
Gene Symbols: GABRA3
Molecular weight: 55,165 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below

GABRA3

Protein Structure Not Found.
Download PyMol Script
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T91‑p PGLGDAVtEVKTDIY
0 1 T384‑p ALEMKKKtPAAPAKK
0 4 S423 ISKGAAPSASSTPTI
0 1 S426 GAAPSASSTPTIIAS
0 3 T427 AAPSASSTPTIIASP
0 9 S433 STPTIIASPKATYVQ
0 2 S442 KATYVQDSPTETKTY
  mouse

 
T91 PGLGDAVTEVKTDIY
T384 ALEMKKKTPAAPTKK
S423‑p SKSAAAPsASstPTA
S426‑p AAAPsASstPTAIAs
T427‑p AAPsASstPTAIAsP
S433‑p stPTAIAsPKATYVQ
S442‑p KATYVQDsPAETKTY
  rat

 
T91 PGLGDAVTEVKTDIY
T384 ALEMKKKTPAAPTKK
S424 SKAAAAPSASSTPTV
S427 AAAPSASSTPTVIAs
T428 AAPSASSTPTVIAsP
S434‑p STPTVIAsPKTTYVQ
S443 KTTYVQDSPAETKTY
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