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Protein Page:
SCN10A (human)

SCN10A This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p22.2
Cellular Component: voltage-gated sodium channel complex
Molecular Function: voltage-gated sodium channel activity
Biological Process: generation of action potential; regulation of heart rate; sensory perception
Disease: Episodic Pain Syndrome, Familial, 2
Reference #:  Q9Y5Y9 (UniProtKB)
Alt. Names/Synonyms: hPN3; Nav1.8; Peripheral nerve sodium channel 3; PN3; SCN10A; SCNAA; SNS; Sodium channel protein type 10 subunit alpha; Sodium channel protein type X subunit alpha; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.8
Gene Symbols: SCN10A
Molecular weight: 220,626 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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