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PUMA
essential mediator of p53-dependent and independent apoptosis. Binds to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Interacts with BCL2, BCL2L1, MCL1 and BCL2A1. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53. Regulates ER stress-induced neuronal apoptosis. Induced by DNA damage, glucocorticoid treatment, growth factor deprivation and p53. Ubiquitously expressed. Ubiquitously expressed. Belongs to the Bcl-2 family, BH3-only pro-apoptotic subclass. Four isoforms of the human protein are apparently produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Mitochondrial |
| Chromosomal Location of Human Ortholog: 1q21 |
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Cellular Component: lysosome; mitochondrion
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Molecular Function: ATPase binding; glycoprotein binding; protein binding
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Biological Process: apoptosis; brain development; caspase activation; determination of adult life span; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of growth; positive regulation of apoptosis; positive regulation of neuron apoptosis; positive regulation of protein homooligomerization; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria; release of sequestered calcium ion into cytosol; response to DNA damage stimulus
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Reference #:
Q80ZG6
(UniProtKB)
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Alt. Names/Synonyms: Bbc3; Bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; Puma
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Gene Symbols: Bbc3
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Molecular weight:
20,718 Da
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Basal Isoelectric point:
6.91
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Mitochondrial Control of Apoptosis
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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