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Protein Page:
CXCL10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CXCL10 Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Chemokine
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: extracellular region; extracellular space
Molecular Function: cAMP-dependent protein kinase regulator activity; chemokine activity; CXCR3 chemokine receptor binding; heparin binding; protein binding; receptor binding
Biological Process: blood circulation; cell surface receptor linked signal transduction; cell-cell signaling; chemotaxis; endothelial cell activation; G-protein coupled receptor protein signaling pathway; immune response; muscle development; positive regulation of cAMP metabolic process; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; signal transduction
Reference #:  P02778 (UniProtKB)
Alt. Names/Synonyms: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C7; chemokine (C-X-C motif) ligand 10; crg-2; CXCL10; CXCL10(1-73); CXL10; gamma IP10; Gamma-IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10
Gene Symbols: CXCL10
Molecular weight: 10,881 Da
Basal Isoelectric point: 9.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CXCL10

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K67‑ac VEIIATMkkkGEkRC
0 1 K68‑ac EIIATMkkkGEkRCL
0 2 K69‑ac IIATMkkkGEkRCLN
0 3 K72‑ac TMkkkGEkRCLNPES
0 1 K80‑ac RCLNPESkAIKNLLK
  mouse

 
K67 VEIIATMKKNDEQRC
K68 EIIATMKKNDEQRCL
N69 IIATMKKNDEQRCLN
Q72 TMKKNDEQRCLNPES
K80 RCLNPESKTIKNLMK
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