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Protein Page:
IL1RAPL1 (human)

Overview
IL1RAPL1 May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: Xp22.1-p21.3
Cellular Component: cell surface; dendrite; plasma membrane
Molecular Function: interleukin-1 binding; protein binding; receptor binding; voltage-gated calcium channel activity
Biological Process: heterophilic cell adhesion; negative regulation of exocytosis; neuron differentiation; positive regulation of dendrite morphogenesis
Disease: Mental Retardation, X-linked 21
Reference #:  Q9NZN1 (UniProtKB)
Alt. Names/Synonyms: IL-1-RAPL-1; IL-1RAPL-1; IL1R8; IL1RAPL; IL1RAPL-1; IL1RAPL1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; Interleukin-1 receptor accessory protein-like 1; IRPL1; mental retardation, X-linked 10; MRX10; MRX21; MRX34; Oligophrenin-4; OPHN4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
Gene Symbols: IL1RAPL1
Molecular weight: 79,969 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
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IL1RAPL1

Protein Structure Not Found.
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