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Protein Page:
PREB (human)

Overview
PREB Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER. Note: This description may include information from UniProtKB.
Protein type: GEFs, misc.; Membrane protein, integral; Transcription factor
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane; nucleus
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Sar guanyl-nucleotide exchange factor activity
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; protein exit from endoplasmic reticulum
Reference #:  Q9HCU5 (UniProtKB)
Alt. Names/Synonyms: Mammalian guanine nucleotide exchange factor mSec12; MGC3467; PREB; prolactin regulatory binding-element protein; prolactin regulatory element binding; Prolactin regulatory element-binding protein; SEC12
Gene Symbols: PREB
Molecular weight: 45,468 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
Select Structure to View Below

PREB

Protein Structure Not Found.


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