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Protein Page:
RIPK2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RIPK2 a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; RIPK family
Cellular Component: cytoplasm; cytoskeleton; protein complex; vesicle
Molecular Function: CARD domain binding; LIM domain binding; protein homodimerization activity; receptor binding
Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; defense response to Gram-positive bacterium; I-kappaB kinase/NF-kappaB cascade; innate immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis; positive regulation of chemokine production; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of immature T cell proliferation; positive regulation of interferon-gamma production; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein ubiquitination; positive regulation of stress-activated MAPK cascade; positive regulation of T-helper 1 cell differentiation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor production; regulation of caspase activity; response to exogenous dsRNA; T cell proliferation; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  P58801 (UniProtKB)
Alt. Names/Synonyms: 2210420D18Rik; CARD3; CARDIAK; CCK; D4Bwg0615e; OTTMUSP00000004983; receptor (TNFRSF)-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RICK; RIP2; Ripk2
Gene Symbols: Ripk2
Molecular weight: 60,400 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RIPK2

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K17 LPPIPYHKLADLHYL
0 1 Y23 HKLADLHYLSRGASG
0 4 S168 KIADFGLSKWRMMSL
0 3 S174 LSKWRMMSLsQsRsy
2 36 S176‑p KWRMMSLsQsRsyKS
0 16 S178‑p RMMSLsQsRsyKSAP
0 1 S180‑p MSLsQsRsyKSAPEG
0 2 Y181‑p SLsQsRsyKSAPEGG
0 2 K182 LsQsRsyKSAPEGGT
0 2 K203‑ub ENYEPGQkSRASVkH
2 0 K209‑ub QkSRASVkHDIYSYA
0 1 S331‑p CDKKMDLsLNIPANH
0 1 S344 NHPPQEESCGSSLLS
0 2 S356‑p LLSRNTGsPGPsRSL
0 1 S360‑p NTGsPGPsRSLsAPQ
0 10 S362 GsPGPsRSLsAPQDK
0 3 S364‑p PGPsRSLsAPQDKGF
0 357 S380 SGAPQDCSSLKAHHC
0 6 S392‑p HHCPGNHsWDGIVsV
0 1 S398‑p HsWDGIVsVPPGAAF
0 1 A410 AAFCDRRAssCsLAV
0 13 S411‑p AFCDRRAssCsLAVI
0 6 S412‑p FCDRRAssCsLAVIs
0 5 S414‑p DRRAssCsLAVIsPF
0 1 S419‑p sCsLAVIsPFLVEKG
3 1 Y473 DLIMKEDYELISTKP
0 11 S526 YPEVPVLSKAPPSNF
0 9 A528 EVPVLSKAPPSNFPQ
0 30 P530 PVLSKAPPSNFPQNK
0 8 S538‑p SNFPQNKsL______
  human

► Hide Isoforms
 
K17‑ub LPTIPYHkLADLRyL
Y23‑p HkLADLRyLSRGASG
S168‑p KIADFGLsKWRMMsL
S174‑p LsKWRMMsLsQsRSs
S176‑p KWRMMsLsQsRSskS
S178‑p RMMsLsQsRSskSAP
S180 MsLsQsRSskSAPEG
S181‑p sLsQsRSskSAPEGG
K182‑ub LsQsRSskSAPEGGT
K203‑ub ENYEPGQkSRASIkH
K209‑ub QkSRASIkHDIYSYA
S332 DKKKMELSLNIPVNH
S345‑p NHGPQEEsCGSSQLH
S357‑p QLHENSGsPETSRsL
S361 NSGsPETSRsLPAPQ
S363‑p GsPETSRsLPAPQDN
P365 PETSRsLPAPQDNDF
Y381‑p SRKAQDCyFMKLHHC
S393‑p HHCPGNHsWDSTISG
S399 HsWDSTISGSQRAAF
T411‑p AAFCDHKtTPCSSAI
T412 AFCDHKtTPCSSAII
P413 FCDHKtTPCSSAIIN
S415 DHKtTPCSSAIINPL
N420 PCSSAIINPLSTAGN
Y474‑p DLIMKEDyELVSTKP
S527‑p YPEILVVsRsPsLNL
S529‑p EILVVsRsPsLNLLQ
S531‑p LVVsRsPsLNLLQNK
S539‑p LNLLQNKsM______
4364 : Phospho-RIP2 (Ser176) Antibody
14397 : Phospho-RIP2 (Ser176) (E1I9J) Rabbit mAb
  RIPK2 iso2  
- gap
- gap
S31 KIADFGLSKWRMMSL
S37 LSKWRMMSLSQSRSS
S39 KWRMMSLSQSRSSKS
S41 RMMSLSQSRSSKSAP
S43 MSLSQSRSSKSAPEG
S44 SLSQSRSSKSAPEGG
K45 LSQSRSSKSAPEGGT
K66 ENYEPGQKSRASIKH
K72 QKSRASIKHDIYSYA
S195 DKKKMELSLNIPVNH
S208 NHGPQEESCGSSQLH
S220 QLHENSGSPETSRSL
S224 NSGSPETSRSLPAPQ
S226 GSPETSRSLPAPQDN
P228 PETSRSLPAPQDNDF
Y244 SRKAQDCYFMKLHHC
S256 HHCPGNHSWDSTISG
S262 HSWDSTISGSQRAAF
T274 AAFCDHKTTPCSSAI
T275 AFCDHKTTPCSSAII
P276 FCDHKTTPCSSAIIN
S278 DHKTTPCSSAIINPL
N283 PCSSAIINPLSTAGN
Y337 DLIMKEDYELVSTKP
S390 YPEILVVSRSPSLNL
S392 EILVVSRSPSLNLLQ
S394 LVVSRSPSLNLLQNK
S402 LNLLQNKSM______
  rat

 
K17 LPHIPYHKLADLHYL
Y23 HKLADLHYLSRGASG
S168 KIADFGLSKWRMMSL
S174 LSKWRMMSLSQSRSY
S176 KWRMMSLSQSRSYKS
S178 RMMSLSQSRSYKSAP
S180 MSLSQSRSYKSAPEG
Y181 SLSQSRSYKSAPEGG
K182 LSQSRSYKSAPEGGT
K203 ENYEPGQKSRASVKH
K209 QKSRASVKHDIYSYA
S331 CDKKMDLSLNIPASH
S344 SHPPQEESCGSSLLS
S356 LLSRNAGSPGTSRSL
S360 NAGSPGTSRSLSAPQ
S362 GSPGTSRSLSAPQDK
S364 PGTSRSLSAPQDKGF
S380 HGGPQDCSSSKAYHC
S392 YHCPGNHSWDGIISV
S398 HSWDGIISVSQEAAF
A410 AAFCDRRAssCsLTV
S411‑p AFCDRRAssCsLTVI
S412‑p FCDRRAssCsLTVIR
S414‑p DRRAssCsLTVIRPL
R419 sCsLTVIRPLLVEKS
Y473 DLIMKEDYELISTKP
S526 YPEVLLVSRTPSSNV
T528 EVLLVSRTPSSNVLQ
S530 LLVSRTPSSNVLQNK
T538 SNVLQNKTL______
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