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MCL1
a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial |
| Chromosomal Location of Human Ortholog: 3 F2.1|3 40.74 cM |
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Cellular Component: cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleus
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Molecular Function: BH domain binding; BH3 domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity
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Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of apoptosis; negative regulation of autophagy; response to cytokine stimulus
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Reference #:
P97287
(UniProtKB)
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Alt. Names/Synonyms: AW556805; Bcl-2-related protein EAT/mcl1; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl-1; Mcl1; myeloid cell leukemia sequence 1
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Gene Symbols: Mcl1
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Molecular weight:
35,217 Da
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Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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IL6 Signaling
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Inhibition of Apoptosis
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Mitochondrial Control of Apoptosis
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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