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Protein Page:
SMPD1 (human)

Overview
SMPD1 Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity. Monomer. Belongs to the acid sphingomyelinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.12; Phosphodiesterase; Lipid Metabolism - sphingolipid
Chromosomal Location of Human Ortholog: 11p15.4-p15.1
Cellular Component: endosome; extracellular space; lamellar body; lysosomal lumen; lysosome; plasma membrane
Molecular Function: hydrolase activity, acting on glycosyl bonds; protein binding; sphingomyelin phosphodiesterase activity; zinc ion binding
Biological Process: ceramide biosynthetic process; glycosphingolipid metabolic process; negative regulation of MAP kinase activity; nervous system development; positive regulation of apoptosis; positive regulation of protein amino acid dephosphorylation; response to cocaine; response to drug; signal transduction; sphingomyelin catabolic process; sphingomyelin metabolic process
Disease: Niemann-pick Disease, Type A; Niemann-pick Disease, Type B
Reference #:  P17405 (UniProtKB)
Alt. Names/Synonyms: Acid sphingomyelinase; ASM; aSMase; NPD; SMPD1; Sphingomyelin phosphodiesterase; sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbols: SMPD1
Molecular weight: 69,752 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMPD1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S508‑p
intracellular localization: S508‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S231‑p PLCCRRGsGLPPASR
2 0 S508‑p DGNYSGSsHVVLDHE
  mouse

 
S229 PLCCRRGSGWPPNSQ
S506 DGNYPGSSHVVLDHE
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