a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage
Molecular Function: ATP-dependent DNA helicase activity; damaged DNA binding; protein binding; protein N-terminus binding; transcription factor binding
Biological Process: cell cycle arrest; DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator; DNA double-strand break processing; DNA duplex unwinding; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; mitotic cell cycle checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of DNA replication initiation; strand displacement; telomere maintenance; telomeric 3' overhang formation