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Protein Page:
NUPL2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NUPL2 Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleoporin
Chromosomal Location of Human Ortholog: 7p15
Cellular Component: cytoplasm; cytosol; nuclear membrane; nuclear pore; nucleoplasm; nucleus; photoreceptor outer segment
Molecular Function: metal ion binding; nuclear export signal receptor activity
Biological Process: carbohydrate metabolic process; cellular protein metabolic process; cytokine and chemokine mediated signaling pathway; gene expression; glucose transport; hexose transport; mitotic cell cycle; mitotic nuclear envelope disassembly; modification by virus of host cellular process; mRNA transport; post-translational protein modification; protein export from nucleus; protein sumoylation; RNA-mediated gene silencing; transmembrane transport; tRNA processing; viral infectious cycle; viral reproduction; viral transcription; virus-host interaction
Reference #:  O15504 (UniProtKB)
Alt. Names/Synonyms: CG1; H_RG271G13.9; hCG1; NLP-1; NLP_1; Nucleoporin hCG1; nucleoporin like 2; nucleoporin-like protein 1; Nucleoporin-like protein 2; NUP42 homolog; NUPL2
Gene Symbols: NUPL2
Molecular weight: 44,872 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Select Structure to View Below

NUPL2

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K65‑ub IQPSSFSkSTPWGGS
0 2 Y79‑p SRDQEKPyFSsFDSG
0 1 S82‑p QEKPyFSsFDSGAST
0 1 S85 PyFSsFDSGASTNRK
0 1 S88 SsFDSGASTNRKEGF
0 1 S104‑p LSENPFAsLsPDEQK
0 9 S106‑p ENPFAsLsPDEQKDE
0 1 Y138‑p GQWMFSVysPVKKKP
0 1 S139‑p QWMFSVysPVKKKPN
0 2 S305‑p AASFSFKsPAASSFG
0 1 S313‑p PAASSFGsPGFSGLP
0 1 S347‑p SSVAGFGsPGSHSHT
  NUPL2 iso2  
K65 IQPSSFSKSTPWGGS
Y79 SRDQEKPYFSSFDSG
S82 QEKPYFSSFDSGAST
S85 PYFSSFDSGASTNRK
S88 SSFDSGASTNRKEGF
S104 LSENPFASLSPDEQK
S106 ENPFASLSPDEQKDE
Y138 GQWMFSVYSPVKKKP
S139 QWMFSVYSPVKKKPN
- gap
- gap
- gap
  mouse

 
K67 IQPSSFPKSTPWGGS
P81 SRDQDKPPFGSFDSG
S84 QDKPPFGSFDSGAsT
S87 PPFGSFDSGAsTSRG
S90‑p GSFDSGAsTSRGFGS
S104 SSQNPFASPLSDEQK
S107 NPFASPLSDEQKDEK
Y138 GQWMFSVYSPVRKKP
S139 QWMFSVYSPVRKKPN
S305 AASFSFKSPEASSFA
S313 PEASSFASPGFSGFP
S347 SSVVGFGSPSPHSQA
  rat

 
K67 IQPSSFSKSTPWGGS
P81 SRGQDKPPFGPFDsG
P84 QDKPPFGPFDsGAST
S87‑p PPFGPFDsGASTSRG
S90 GPFDsGASTSRGFGS
S104 SPQNPFASPLsDEQK
S107‑p NPFASPLsDEQKDEK
Y138 GQWMFSVYSPVRKKP
S139 QWMFSVYSPVRKKPN
S305 AASFSFKSPEASSFG
S313 PEASSFGSPGFSGFP
S345 SSVAAFGSPSPHSQT
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