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Protein Page:
CPN1 (human)

CPN1 Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q24.2
Molecular Function: serine carboxypeptidase activity
Biological Process: peptide metabolic process; protein processing
Disease: Carboxypeptidase N Deficiency
Reference #:  P15169 (UniProtKB)
Alt. Names/Synonyms: ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N catalytic chain; carboxypeptidase N catalytic subunit; Carboxypeptidase N polypeptide 1; carboxypeptidase N polypeptide 1 50 kD; Carboxypeptidase N small subunit; carboxypeptidase N, polypeptide 1; CBPN; CPN; CPN1; FLJ40792; kininase I; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; SCPN; Serum carboxypeptidase N
Gene Symbols: CPN1
Molecular weight: 52,286 Da
Basal Isoelectric point: 6.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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