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Protein Page:
LIPC (human)

Overview
LIPC Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.1.3; Lipid Metabolism - glycerolipid; Phospholipase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q21-q23
Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space
Molecular Function: apolipoprotein binding; low-density lipoprotein binding; phospholipase activity; triacylglycerol lipase activity
Biological Process: cholesterol homeostasis; fatty acid biosynthetic process; lipid digestion; reverse cholesterol transport; triacylglycerol catabolic process
Disease: Diabetes Mellitus, Noninsulin-dependent; Hepatic Lipase Deficiency; High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12
Reference #:  P11150 (UniProtKB)
Alt. Names/Synonyms: HDLCQ12; Hepatic lipase; Hepatic triacylglycerol lipase; HL; HTGL; Lipase member C; lipase, hepatic; LIPC; LIPH
Gene Symbols: LIPC
Molecular weight: 55,914 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Select Structure to View Below

LIPC

Protein Structure Not Found.


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