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Protein Page:
LIPC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

LIPC Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; EC; Secreted; Lipid Metabolism - glycerolipid; Phospholipase
Chromosomal Location of Human Ortholog: 15q21-q23
Cellular Component: cell surface; early endosome; endoplasmic reticulum lumen; extracellular region; extracellular space; late endosome; microvillus
Molecular Function: acylglycerol lipase activity; apolipoprotein binding; heparan sulfate proteoglycan binding; heparin binding; lipid binding; low-density lipoprotein binding; lysophospholipase activity; phospholipase A1 activity; phospholipase activity; transferase activity, transferring acyl groups; triacylglycerol lipase activity
Biological Process: cellular response to hormone stimulus; cholesterol homeostasis; cholesterol metabolic process; circadian rhythm; developmental growth; fatty acid biosynthetic process; heparan sulfate proteoglycan biosynthetic process; lipid digestion; liver development; phosphatidic acid metabolic process; phosphatidylethanolamine metabolic process; phosphatidylserine metabolic process; protein oligomerization; response to acetate; response to amino acid stimulus; response to calcium ion; response to carbohydrate stimulus; response to copper ion; response to drug; response to glucocorticoid stimulus; response to hypoxia; response to magnesium ion; response to nutrient levels; response to peptide hormone stimulus; reverse cholesterol transport; triacylglycerol catabolic process
Disease: Diabetes Mellitus, Noninsulin-dependent; Hepatic Lipase Deficiency; High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12
Reference #:  P11150 (UniProtKB)
Gene Symbols: LIPC
Molecular weight: 55,914 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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