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Protein Page:
FGF3 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGF3 Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Defects in FGF3 are a cause of deafness with labyrinthine aplasia, microtia and microdontia (LAMM); also known as congenital deafness with inner ear agenesis, microtia and microdontia. LAMM consists of a unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia). Belongs to the heparin-binding growth factors family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Oncoprotein; Secreted
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: extracellular region; Golgi apparatus
Molecular Function: fibroblast growth factor receptor binding; growth factor activity; protein binding
Biological Process: activation of MAPKK activity; anatomical structure morphogenesis; axon guidance; cell-cell signaling; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; induction of an organ; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of cardiac muscle development; nerve growth factor receptor signaling pathway; otic vesicle formation; phosphoinositide-mediated signaling; positive regulation of cell division; positive regulation of cell proliferation; Ras protein signal transduction; semicircular canal morphogenesis; signal transduction; small GTPase mediated signal transduction; thymus development; vascular endothelial growth factor receptor signaling pathway
Disease: Deafness, Congenital, With Inner Ear Agenesis, Microtia, And Microdontia
Reference #:  P11487 (UniProtKB)
Alt. Names/Synonyms: FGF-3; FGF3; Fibroblast growth factor 3; fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog); HBGF-3; Heparin-binding growth factor 3; INT-2 proto-oncogene protein; INT2; murine mammary tumor virus integration site 2, mouse; oncogene INT2; Proto-oncogene Int-2; V-INT2 murine mammary tumor virus integration site oncogene homolog
Gene Symbols: FGF3
Molecular weight: 26,887 Da
Basal Isoelectric point: 10.88  Predict pI for various phosphorylation states
Select Structure to View Below

FGF3

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R32‑m1 LRRDAGGrGGVYEHL
0 1 R44‑m1 EHLGGAPrrRKLYCA
0 1 R45‑m1 HLGGAPrrRKLYCAT
0 1 S93‑p VAIRGLFsGRyLAMN
0 1 Y96‑p RGLFsGRyLAMNKRG
0 1 T136‑p YASRLYRtVssTPGA
0 1 S138‑p SRLYRtVssTPGARR
0 1 S139‑p RLYRtVssTPGARRQ
0 1 S176‑p TRRTQKSsLFLPRVL
  mouse

 
R32 LRRDAGGRGGVYEHL
R44 EHLGGAPRRRKLYCA
R45 HLGGAPRRRKLYCAT
S93 VAIKGLFSGRYLAMN
Y96 KGLFSGRYLAMNKRG
T136 YASRLYRTGSSGPGA
S138 SRLYRTGSSGPGAQR
S139 RLYRTGSSGPGAQRQ
S176 TRRTQKSSLFLPRVL
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