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Protein Page:
GLI2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLI2 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. Interaction with ZIC. Belongs to the GLI C2H2-type zinc-finger protein family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; C2H2-type zinc finger protein; Oncoprotein
Cellular Component: axoneme; cilium; cytoplasm; membrane; motile primary cilium; nuclear speck; nucleus
Molecular Function: chromatin binding; DNA binding; metal ion binding; nucleic acid binding; protein binding; sequence-specific DNA binding; transcription factor activity; zinc ion binding
Biological Process: anatomical structure development; anatomical structure formation; anterior/posterior pattern formation; axon guidance; branching morphogenesis of a tube; cell differentiation; cell proliferation; cerebellar cortex morphogenesis; chondrocyte differentiation; developmental growth; dorsal/ventral pattern formation; dorsoventral neural tube patterning; embryonic digit morphogenesis; embryonic gut development; epidermal cell differentiation; floor plate formation; heart development; hindbrain development; hindgut morphogenesis; in utero embryonic development; kidney development; lung development; mammary gland development; morphogenesis of an epithelium; multicellular organismal development; negative regulation of apoptosis; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; neuron development; notochord regression; odontogenesis of dentine-containing teeth; osteoblast development; osteoblast differentiation; pattern specification process; pituitary gland development; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proximal/distal pattern formation; regulation of smoothened signaling pathway; regulation of transcription, DNA-dependent; skeletal development; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; spinal cord dorsal/ventral patterning; spinal cord motor neuron differentiation; spinal cord ventral commissure morphogenesis; transcription, DNA-dependent; tube development; ventral midline development; ventral spinal cord development
Reference #:  Q0VGT2 (UniProtKB)
Alt. Names/Synonyms: AW546128; GLI-Kruppel family member GLI2; Gli2; Tax helper protein
Gene Symbols: Gli2
Molecular weight: 165,031 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Select Structure to View Below

GLI2

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
protein stabilization: S230‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 P8 METSAPAPALEKKEA
0 1 L10 TSAPAPALEKKEAKS
0 1 T84‑p HSVHGPPtLSGsPVI
0 1 S88‑p GPPtLSGsPVISDIS
0 3 S128 HMEHYLRSVHSSPTL
0 2 S131 HYLRSVHSSPTLSMI
0 1 S132 YLRSVHSSPTLSMIS
0 1 S139 SPTLSMISAARGLSP
1 2 S145 ISAARGLSPADVAHE
0 4 T220 RFSSPRVTPRLSRKR
1 5 S230‑p LSRKRALsISPLSDA
0 3 S232 RKRALsISPLSDASL
0 1 S235 ALsISPLSDASLDLQ
0 1 S238 ISPLSDASLDLQRMI
0 1 S251 MIRTSPNSLVAYINN
0 1 K373 ITIHKRSKVKTEAEG
1 5 S385‑p AEGLRPAsPLGLTQE
0 1 S539 KHQNRTHSNEKPYIC
0 1 Y544 THSNEKPYICKIPGC
0 1 A600 NGDNEASAEPGGRGP
0 1 S610 GGRGPEESVEASSTS
0 1 S614 PEESVEASSTSHTVE
1 0 K630‑sm CLHIKAIkTESSGLC
1 0 K716‑sm VHRFEQLkREKLKSL
1 0 K740‑ac APHTRNTkLPPLPVN
1 3 S789‑p QLQERRDsSTSTMSs
0 1 S796‑p sSTSTMSsAYTVSRR
0 1 T799 STMSsAYTVSRRSsG
0 2 S801 MSsAYTVSRRSsGIS
1 7 S805‑p YTVSRRSsGISPYFS
0 1 S812 sGISPYFSSRRSsEA
1 2 S817‑p YFSSRRSsEASPLGG
0 1 S820 SRRSsEASPLGGLRP
0 1 S831‑p GLRPHNAsSADSYDP
0 1 S840 ADSYDPISTDASRRS
0 1 T841 DSYDPISTDASRRSs
1 0 S848‑p TDASRRSsEASQCSG
0 1 S851 SRRSsEASQCSGGGP
1 1 T885‑p ATGGPPPtPLPGLDR
0 1 H915 ALPGACPHPLGPRRG
1 3 S923‑p PLGPRRGsDGPTYSH
1 8 S956‑p NSSTRRAsDPVRRPD
0 3 S975 PRVQRFHSTHNMNPG
0 1 T976 RVQRFHSTHNMNPGS
0 1 S997 RRGLHVQSHPSVDSN
0 1 S1000 LHVQSHPSVDSNLtR
0 1 T1006‑p PSVDSNLtRNAYsPR
1 0 S1011‑p NLtRNAYsPRPPSIN
0 5 S1016 AYsPRPPSINENVVM
0 2 S1087‑p PENSKLPsPGLQGHR
0 1 S1180 NPQSVQSSSGGLDST
0 1 N1345 PRPPLEPNTASRHRG
  human

► Hide Isoforms
 
T8‑p METSASAtAsEKQEA
S10‑p TSASAtAsEKQEAKS
A88 HGVHGPPALSGSPVI
S92 GPPALSGSPVISDIS
S132‑p HMEHYLRsVHssPTL
S135‑p HYLRsVHssPTLSMI
S136‑p YLRsVHssPTLSMIs
S143‑p sPTLSMIsAARGLsP
S149‑p IsAARGLsPADVAQE
T224‑p RFSSPRVtPRLSRKR
S234‑p LSRKRALsIsPLsDA
S236‑p RKRALsIsPLsDAsL
S239‑p ALsIsPLsDAsLDLQ
S242‑p IsPLsDAsLDLQRMI
S255‑p MIRTSPNsLVAYINN
K376 VAIHKRSKVKTEPEG
S388‑p PEGLRPAsPLALTQG
S559 KHQNRTHSNEKPYIC
Y564 THSNEKPYICKIPGC
T620 NGDSEAGTEPGGPES
S627 TEPGGPESTEASSTS
S631 GPESTEASSTSQAVE
K647 CLHVRAIKTESSGLC
K733 MHRFEQLKKEKLKSL
K757‑ac TPHTRNTkLPPLPGS
S808‑p QLQERRDsSTSTVSS
S815 sSTSTVSSAYtVsRR
T818‑p STVSSAYtVsRRSsG
S820‑p VSSAYtVsRRSsGIS
S824‑p YtVsRRSsGISPYFs
S831‑p sGISPYFsSRRSsEA
S836‑p YFsSRRSsEAsPLGA
S839‑p SRRSsEAsPLGAGRP
S850 AGRPHNASSADSYDP
S859‑p ADSYDPIstDASRRS
T860‑p DSYDPIstDASRRSS
S867 tDASRRSSEAsQCSG
S870‑p SRRSSEAsQCSGGSG
T903 ATGGPPPTPLPGLER
R933 TLPAGCPRPLGPRRG
S941‑p PLGPRRGsDGPTYGH
S970‑p GGGARRAsDPVRRPD
S989‑p PRVQRFHstHNVNPG
T990‑p RVQRFHstHNVNPGP
S1011 RRGLRLQSHPsTDGG
S1014‑p LRLQSHPsTDGGLAR
A1020 PsTDGGLARGAYSPR
S1025 GLARGAYSPRPPsIS
S1030‑p AYSPRPPsISENVAM
S1101‑p SDNPRLPsPGLHGQR
S1194 SPQGLQASPGGLDST
S1378‑p PRPPLEPsPTGRHRG
  GLI2 iso1  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K48‑ac VAIHKRSkVKTEPEG
S60 PEGLRPASPLALTQG
S231‑p KHQNRTHsNEKPyIC
Y236‑p THsNEKPyICKIPGC
T292‑p NGDSEAGtEPGGPEs
S299‑p tEPGGPEsTEAsSTS
S303‑p GPEsTEAsSTSQAVE
K319 CLHVRAIKTESSGLC
K405 MHRFEQLKKEKLKSL
K429 TPHTRNTKLPPLPGS
S480 QLQERRDSSTSTVSS
S487 SSTSTVSSAYTVSRR
T490 STVSSAYTVSRRSSG
S492 VSSAYTVSRRSSGIS
S496 YTVSRRSSGISPYFS
S503 SGISPYFSSRRSSEA
S508 YFSSRRSSEASPLGA
S511 SRRSSEASPLGAGRP
S522 AGRPHNASSADSYDP
S531 ADSYDPISTDASRRS
T532 DSYDPISTDASRRSS
S539 TDASRRSSEASQCSG
S542 SRRSSEASQCSGGSG
T575 ATGGPPPTPLPGLER
R605‑m2 TLPAGCPrPLGPRRG
S613 PLGPRRGSDGPTYGH
S642 GGGARRASDPVRRPD
S661 PRVQRFHSTHNVNPG
T662 RVQRFHSTHNVNPGP
S683‑p RRGLRLQsHPSTDGG
S686 LRLQsHPSTDGGLAR
A692 PSTDGGLARGAYSPR
S697 GLARGAYSPRPPsIS
S702‑p AYSPRPPsISENVAM
S773 SDNPRLPSPGLHGQR
S866‑p SPQGLQAsPGGLDST
S1050 PRPPLEPSPTGRHRG
  GLI2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K48 VAIHKRSKVKTEPEG
S60‑p PEGLRPAsPLALTQE
S214 KHQNRTHSNEKPYIC
Y219 THSNEKPYICKIPGC
T275 NGDSEAGTEPGGPES
S282 TEPGGPESTEASSTS
S286 GPESTEASSTSQAVE
K302 CLHVRAIKTESSGLC
K388 MHRFEQLKKEKLKSL
K412 TPHTRNTKLPPLPGS
S463 QLQERRDSSTSTVSS
S470 SSTSTVSSAYTVSRR
T473 STVSSAYTVSRRSSG
S475 VSSAYTVSRRSSGIS
S479 YTVSRRSSGISPYFS
S486 SGISPYFSSRRSSEA
S491 YFSSRRSSEASPLGA
S494 SRRSSEASPLGAGRP
S505 AGRPHNASSADSYDP
S514 ADSYDPISTDASRRS
T515 DSYDPISTDASRRSS
S522 TDASRRSSEASQCSG
S525 SRRSSEASQCSGGSG
T558 ATGGPPPTPLPGLER
R588 TLPAGCPRPLGPRRG
S596 PLGPRRGSDGPTYGH
S625 GGGARRASDPVRRPD
S644 PRVQRFHSTHNVNPG
T645 RVQRFHSTHNVNPGP
S666 RRGLRLQSHPSTDGG
S669 LRLQSHPSTDGGLAR
A675 PSTDGGLARGAYSPR
S680 GLARGAYSPRPPSIS
S685 AYSPRPPSISENVAM
S756 SDNPRLPSPGLHGQR
S849 SPQGLQASPGGLDST
S1033 PRPPLEPSPTGRHRG
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