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Protein Page:
MEKK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MEKK1 a protein kinase of the STE11 family. Phosphorylates and activates MKK4 and -7, which in turn activate JNK1, -2 and -3. Contains 1 RING-type zinc finger. The RING finger domain of MEKK1 exhibits E3 ubiquitin ligase activity toward c-Jun. c-Jun is downregulated in response to osmotic stress via ubiquitination-mediated degradation by the RING finger domain of MEKK1. Overexpressed/overactivated in multiple tumor types. The Mek1/2 inhibitor U0126 blocks export of influenza viral particles and has been suggested as an antiviral treatment. Single mutations at the same point of each gene also associated with cardiofaciocutaneous syndrome, (also linked with Braf and Kras mutations), displaying morphological, cardiac and mental defects. Inhibitors: U0126, CI-1040/PD184352, PD-0325901 (Phase I cancer), ARRY-142886 (Phase 1, cancer). Note: This description may include information from UniProtKB.
Protein type: Ligase; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; Ubiquitin conjugating system; Kinase, protein; Ubiquitin ligase; Protein kinase, STE; STE group; STE11 family
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: apoptosis; MyD88-dependent toll-like receptor signaling pathway
Disease: 46,xy Sex Reversal 6
Reference #:  Q13233 (UniProtKB)
Alt. Names/Synonyms: M3K1; MAP/ERK kinase kinase 1; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK; MEKK 1; MEKK1; Mitogen-activated protein kinase kinase kinase 1
Gene Symbols: MAP3K1
Molecular weight: 164,470 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Select Structure to View Below

MEKK1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S67‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T20‑p GFPGARAtsPEAGGG
0 11 S21‑p FPGARAtsPEAGGGG
0 4 S35‑p GGALKASsAPAAAAG
2 1 S67‑p RQLRKVRsVELDQLP
0 4 S133‑p ESVAAPDsGASsPAA
0 13 S137‑p APDsGASsPAAAEPG
0 4 S154‑p RAPAAEPsPAAAPAG
0 2 S232‑p MNHLAAEsPGEVQAS
0 1 S242‑p EVQASAAsPASKGRR
0 4 S250‑p PASKGRRsPsPGNSP
0 3 S252‑p SKGRRsPsPGNSPSG
0 1 S264‑p PSGRTVKsEsPGVRR
0 7 S266‑p GRTVKsEsPGVRRKR
0 17 S275‑p GVRRKRVsPVPFQsG
0 2 S281‑p VsPVPFQsGRItPPR
0 4 T285‑p PFQsGRItPPRRAPs
0 16 S292‑p tPPRRAPsPDGFsPY
0 3 S297‑p APsPDGFsPYsPEET
0 3 S300‑p PDGFsPYsPEETNRR
0 1 S333‑p SFLIGGDsPDNKYRV
0 1 S429 SSSSTSTSSsENSIk
0 1 S430 SSSTSTSSsENSIkD
0 1 S431‑p SSTSTSSsENSIkDE
0 1 K436‑sm SSsENSIkDEEEQMC
0 8 S507‑p FYSHELSsPVDsPSS
0 4 S511‑p ELSsPVDsPSSLRAA
0 1 T522‑p LRAAQQQtVQQQPLA
0 1 V523 RAAQQQtVQQQPLAG
0 3 S531‑p QQQPLAGsRRNQESN
0 1 T542‑p QESNFNLtHYGTQQI
0 1 T657‑p VYVAALKtLRAMLVY
0 1 T665‑p LRAMLVYtPCHSLAE
0 1 T686‑p LLQPVVDtILVkCAD
0 1 K690‑ub VVDtILVkCADANSR
0 1 S748 ILGNQTESNNWQELL
0 2 S796‑p IRYKKLLsLLTFALQ
0 1 T799 KKLLsLLTFALQSID
0 1 S810 QSIDNSHSMVGKLSR
0 1 S844‑p LLEMLSVsSSTHFtR
0 2 T850‑p VsSSTHFtRMRRRLM
0 2 T918 TGKGLCATKLSAsSE
0 1 S921 GLCATKLSAsSEDIS
0 29 S923‑p CATKLSAsSEDISER
0 2 S924 ATKLSAsSEDISERL
0 1 T999‑p SVPAGTAtDVSKHRL
0 5 S1016‑p FIPCRIPsAsPQTQR
0 13 S1018‑p PCRIPsAsPQTQRKF
0 11 S1026‑p PQTQRKFsLQFHRNC
0 3 S1043‑p NKDSDKLsPVFTQSR
0 2 T1082‑p DPSKNSMtLDLNsSs
0 1 S1087‑p SMtLDLNsSsKCDDS
0 1 S1089‑p tLDLNsSsKCDDSFG
0 2 T1114‑p PSDETVFtPVEEKCR
0 4 S1157‑p KSEVAVLsPEKAEND
0 3 K1168‑ub AENDDTYkDDVNHNQ
0 2 K1176‑ub DDVNHNQkCKEKMEA
0 1 Y1338‑p VAHLLSKyGAFKESV
0 17 K1398‑ub AAARLASkGTGAGEF
3 0 T1400 ARLASkGTGAGEFQG
1 0 T1412 FQGQLLGTIAFMAPE
0 3 S1455‑p PWNAEKHsNHLALIF
0 1 S1466 ALIFKIASATTAPSI
0 1 T1469 FKIASATTAPSIPSH
0 1 S1475 TTAPSIPSHLSPGLR
0 1 S1478 PSIPSHLSPGLRDVA
  mouse

 
A20 GFPGAAAASPEAGGG
S21 FPGAAAASPEAGGGG
G38 GGALQGSGAPAAGAA
S71‑p RQLRKVRsVELDQLP
S138 ELAAARDSGARsPAG
S142‑p ARDSGARsPAGAEPP
S150 PAGAEPPSAAAPSGR
P227 VNNLAAEPQGEGQAG
A237 EGQAGSAAPAPKGRR
S245‑p PAPKGRRsPsPGSSP
S247‑p PKGRRsPsPGSSPSG
P259 PSGRSVKPEsPGVRR
S261‑p GRSVKPEsPGVRRKR
S270‑p GVRRKRVsPVPFQSG
S276 VsPVPFQSGRItPPR
T280‑p PFQSGRItPPRRAPs
S287‑p tPPRRAPsPDGFSPY
S292 APsPDGFSPYSPEET
S295 PDGFSPYSPEETSRR
S328 SFLIGGDSPDNKYRV
S424‑p SSSSTSTssSENSIK
S425‑p SSSTSTssSENSIKD
S426 SSTSTssSENSIKDE
K431 ssSENSIKDEEEQMC
S502‑p FYSHELSsPVESPAS
S506 ELSsPVESPASLRAV
S517 LRAVQQPSsPQQPVA
S518‑p RAVQQPSsPQQPVAG
S526 PQQPVAGSQRRNQES
T538 QESSFNLTHFGTQQI
T653 VYVAALKTLRAMLVY
T661 LRAMLVYTPCHSLAE
T682 LLRPVVDTILVKCAD
K686 VVDTILVKCADANSR
S744‑p ILGNQAEsNNWQELL
S792‑p IRYKKLLsLLtFALQ
T795‑p KKLLsLLtFALQSID
S806‑p QSIDNSHsMVGKLSR
S840 LVTMLNASGSTHFTR
T846 ASGSTHFTRMRRRLM
T910‑p TGKGLSAtRLSAssE
S913 GLSAtRLSAssEDIS
S915‑p SAtRLSAssEDISDR
S916‑p AtRLSAssEDISDRL
- gap
S997 FVPCKIPSAsPQTQR
S999‑p PCKIPSAsPQTQRKF
S1007‑p PQTQRKFsLQFQRNC
S1024 HRDSDQLSPVFTQSR
T1063 DATKSSMTLDLGSAS
S1068 SMTLDLGSASRCDDS
S1070 TLDLGSASRCDDSFG
T1095 PSDETVFTPVEDKCR
S1138 KSEVAVLSPEKAEND
K1149 AENDDTYKDDVNHNQ
K1157 DDVNHNQKCKEKMEA
Y1319 VAHLLSKYGAFKESV
K1379 AAARLASKGtGAGEF
T1381‑p ARLASKGtGAGEFQG
T1393‑p FQGQLLGtIAFMAPE
S1436 PWNAEKHSNHLALIF
S1447‑p ALIFKIAsATtAPSI
T1450‑p FKIAsATtAPSIPsH
S1456‑p TtAPSIPsHLsPGLR
S1459‑p PSIPsHLsPGLRDVA
  rat

 
A20 GFPGAAAASPEAGGG
S21 FPGAAAASPEAGGGG
G35 GGALQGSGAPAAGAG
S67 QQLRKVRSVELDQLP
S133 ELAAARDSGARsPAG
S137‑p ARDSGARsPAGAEPP
S145 PAGAEPPSAAAPSGR
L222 MSNLAAELQGEGQAG
A232 EGQAGSAAPAPKGRR
S240 PAPKGRRSPSPGSSP
S242 PKGRRSPSPGSSPSG
P254 PSGRSGKPESPGVRR
S256 GRSGKPESPGVRRKR
S265 GVRRKRVSPVPFQSG
S271 VSPVPFQSGRITPPR
T275 PFQSGRITPPRRAPS
S282 TPPRRAPSPDGFSPY
S287 APSPDGFSPYSPEET
S290 PDGFSPYSPEETSRR
S323 SFLIGGDSPDNKYRV
S419 SSSSTSTSSSENSIK
S420 SSSTSTSSSENSIKD
S421 SSTSTSSSENSIKDE
K426 SSSENSIKDEEEQMC
S497 FYSHELSSPVDSPTS
S501 ELSSPVDSPTSLRGV
S512 LRGVQQPSSPQQPVA
S513 RGVQQPSSPQQPVAG
S521 PQQPVAGSQRRNQES
T533 QESNFNLTHYGTQQI
T648 VYVAALKTLRAMLVY
T656 LRAMLVYTPCHSLAE
T677 LLRPVVDTILVKCAD
K681 VVDTILVKCADANSR
S739 ILGNQAESNNWQELL
S787 IRYKKLLSLLAFALQ
A790 KKLLSLLAFALQSID
S801 QSIDNSHSMVGKLSR
S835 LVTMLSASGSSHFAR
A841 ASGSSHFARMRRRLM
T905‑p TGKGLKAtRLsAssE
S908‑p GLKAtRLsAssEDIS
S910‑p KAtRLsAssEDISDR
S911‑p AtRLsAssEDISDRL
T980 SVPAGSVTDASKHRP
S997 FVPCKIPSASPQTQR
S999 PCKIPSASPQTQRKF
S1007 PQTQRKFSLQFQRTC
S1024 NRDSEKLSPVFTQSR
T1063 DASKNSMTLDLNSAS
S1068 SMTLDLNSASQCDDS
S1070 TLDLNSASQCDDSFG
T1095 PSEETAFTPAEDKCR
S1138 KSEVAVLSPEKAESD
K1149 AESDDTYKDDVNHNQ
K1157 DDVNHNQKCKEKMEA
Y1319 VAHLLSKYGAFKESV
K1379 AAARLASKGTGAGEF
T1381 ARLASKGTGAGEFQG
T1393 FQGQLLGTIAFMAPE
S1436 PWNAEKHSNHLALIF
S1447 ALIFKIASATTAPSI
T1450 FKIASATTAPSIPSH
S1456 TTAPSIPSHLSPGLR
S1459 PSIPSHLSPGLRDVA
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