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Protein Page:
MEKK1 (human)

Overview
MEKK1 a protein kinase of the STE11 family. Phosphorylates and activates MKK4 and -7, which in turn activate JNK1, -2 and -3. Contains 1 RING-type zinc finger. The RING finger domain of MEKK1 exhibits E3 ubiquitin ligase activity toward c-Jun. c-Jun is downregulated in response to osmotic stress via ubiquitination-mediated degradation by the RING finger domain of MEKK1. Overexpressed/overactivated in multiple tumor types. The Mek1/2 inhibitor U0126 blocks export of influenza viral particles and has been suggested as an antiviral treatment. Single mutations at the same point of each gene also associated with cardiofaciocutaneous syndrome, (also linked with Braf and Kras mutations), displaying morphological, cardiac and mental defects. Inhibitors: U0126, CI-1040/PD184352, PD-0325901 (Phase I cancer), ARRY-142886 (Phase 1, cancer). Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: apoptosis; MyD88-dependent toll-like receptor signaling pathway
Disease: 46,xy Sex Reversal 6
Reference #:  Q13233 (UniProtKB)
Alt. Names/Synonyms: M3K1; MAP/ERK kinase kinase 1; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK; MEKK 1; MEKK1; Mitogen-activated protein kinase kinase kinase 1
Gene Symbols: MAP3K1
Molecular weight: 164,470 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Select Structure to View Below

MEKK1

Protein Structure Not Found.


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