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Protein Page:
AVPR1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AVPR1A Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 12q14-q15
Cellular Component: endosome; integral to plasma membrane; plasma membrane
Molecular Function: peptide binding; protein binding; protein kinase C binding
Biological Process: blood circulation; cellular response to hormone stimulus; generation of precursor metabolites and energy; maternal behavior; phospholipase C activation; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin
Reference #:  P37288 (UniProtKB)
Alt. Names/Synonyms: Antidiuretic hormone receptor 1a; arginine vasopressin receptor 1A; AVPR V1a; AVPR1; AVPR1A; SCCL vasopressin subtype 1a receptor; V1-vascular vasopressin receptor AVPR1A; V1a vasopressin receptor; V1aR; Vascular/hepatic-type arginine vasopressin receptor; Vasopressin V1a receptor
Gene Symbols: AVPR1A
Molecular weight: 46,800 Da
Basal Isoelectric point: 9.48  Predict pI for various phosphorylation states
Select Structure to View Below

AVPR1A

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S138 QVFGMFASAYMLVVM
0 1 A139 VFGMFASAYMLVVMT
0 1 Y140 FGMFASAYMLVVMTA
0 1 Y150‑p VVMTADRyIAVCHPL
0 1 K280 APCVSSVKsIsRAKI
0 1 S281‑p PCVSSVKsIsRAKIR
0 1 S283‑p VSSVKsIsRAKIRTV
0 1 S380 FNKEDTDSMSRRQTF
0 1 T386 DSMSRRQTFYSNNRS
0 4 F387 SMSRRQTFYSNNRSP
0 5 S404 STGMWKDSPKssKSI
0 1 S407‑p MWKDSPKssKSIKFI
0 1 S408‑p WKDSPKssKSIKFIP
  mouse

 
S138‑p QVFAMFAssyMLVVM
S139‑p VFAMFAssyMLVVMT
Y140‑p FAMFAssyMLVVMTA
Y150 VVMTADRYIAVCHPL
K285‑ub TPCVSSVkSISRAKI
S286 PCVSSVkSISRAKIR
S288 VSSVkSISRAKIRTV
S385‑p FAKDDSDsMSRRQts
T391‑p DsMSRRQtsYSNNRS
S392‑p sMSRRQtsYSNNRSP
S409‑p STGTWKDsPKSSKSI
S412 TWKDsPKSSKSIRFI
S413 WKDsPKSSKSIRFIP
  rat

 
S138 QVFAMFASAYMLVVM
A139 VFAMFASAYMLVVMT
Y140 FAMFASAYMLVVMTA
Y150 VVMTADRYIAVCHPL
K286 TPCVSSVKSISRAKI
S287 PCVSSVKSISRAKIR
S289 VSSVKSISRAKIRTV
S386 FAKDDSDSMSRRQTS
T392 DSMSRRQTSYSNNRS
S393 SMSRRQTSYSNNRSP
S410 STGMWKDSPKSSKSI
S413 MWKDSPKSSKSIRFI
S414 WKDSPKSSKSIRFIP
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