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Protein Page:
HPK1 (mouse)

Overview
HPK1 a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; STE group; STE20 family; KHS subfamily
Cellular Component: cytoplasm; membrane
Molecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress
Reference #:  P70218 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; Hpk1; M4K1; Map4k1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase kinase 1
Gene Symbols: Map4k1
Molecular weight: 91,535 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HPK1

Protein Structure Not Found.
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Sites Implicated In
transcription, altered: Y379‑p
enzymatic activity, induced: S171‑p, Y379‑p
molecular association, regulation: Y379‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 26 Y28 QRLGGGTYGEVFKAR
2 0 T165 ISAQIGATLARRLsF
3 11 S171‑p ATLARRLsFIGTPYW
2 3 T175 RRLsFIGTPYWMAPE
0 1 Y177 LsFIGTPYWMAPEVA
0 1 N258 VKVTLTKNSKKRPSA
0 4 S319 AIPRRIRSTYRASSL
0 2 A323 RIRSTYRASSLGIPD
0 2 S324 IRSTYRASSLGIPDA
0 4 S325 RSTYRASSLGIPDAD
1 5 C348 QRPRCVDCRPQAETV
1 6 T354 DCRPQAETVRLYPPA
0 3 S365‑p YPPAHFGstsPRsQL
0 2 T366‑p PPAHFGstsPRsQLs
0 2 S367‑p PAHFGstsPRsQLsD
0 1 S370‑p FGstsPRsQLsDsDD
0 5 S373‑p tsPRsQLsDsDDDyD
0 7 S375‑p PRsQLsDsDDDyDDV
0 3 - gap
2 1 Y379‑p LsDsDDDyDDVDIPA
0 10 S403 PPKPKFRSPsDDGSG
0 26 S405‑p KPKFRSPsDDGSGGI
0 17 G411 PsDDGSGGIRDDGQL
0 58 S419‑p IRDDGQLsPGVLVRC
0 25 S428 GVLVRCASGPPPRTP
0 9 T434 ASGPPPRTPRPGPPP
0 2 A442 PRPGPPPATCsPHLT
0 1 C444 PGPPPATCsPHLTAR
0 4 S445‑p GPPPATCsPHLTARs
0 5 T449 ATCsPHLTARsDPSL
0 8 S452‑p sPHLTARsDPSLWNP
0 2 Y567‑p SLSGKTPyLySHSIL
0 1 Y569‑p SGKTPyLySHSILGL
0 4 S592 GSPIAHISPHRLLAR
0 1 S604 LARKNMVSsKIQDTK
0 2 S605‑p ARKNMVSsKIQDTKG
0 1 A743 KLVTPEGAPAPGLRT
  human

 
Y28‑p QRLGGGTyGEVFKAR
T165‑p ISAQIGAtLARRLsF
S171‑p AtLARRLsFIGtPyW
T175‑p RRLsFIGtPyWMAPE
Y177‑p LsFIGtPyWMAPEVA
S258‑p IKVTLTKsPKKRPSA
S320‑p AIPRRIRsTHRsssL
S324‑p RIRsTHRsssLGIPD
S325‑p IRsTHRsssLGIPDA
S326‑p RsTHRsssLGIPDAD
T349‑p RKLRGMEtRPPANtA
T355‑p EtRPPANtARLQPPR
S366‑p QPPRDLRsSsPRKQL
S367 PPRDLRsSsPRKQLs
S368‑p PRDLRsSsPRKQLsE
K371 LRsSsPRKQLsEssD
S374‑p SsPRKQLsEssDDDy
S376‑p PRKQLsEssDDDyDD
S377‑p RKQLsEssDDDyDDV
Y381‑p sEssDDDyDDVDIPT
S405‑p PPKPKFRsPsDEGPG
S407‑p KPKFRsPsDEGPGsM
S413‑p PsDEGPGsMGDDGQL
S421‑p MGDDGQLsPGVLVRC
S430‑p GVLVRCAsGPPPNsP
S436‑p AsGPPPNsPRPGPPP
S444‑p PRPGPPPsTssPHLt
S446‑p PGPPPsTssPHLtAH
S447‑p GPPPsTssPHLtAHs
T451‑p sTssPHLtAHsEPSL
S454‑p sPHLtAHsEPSLWNP
H561 SLSGKTPHLYSHSIL
Y563 SGKTPHLYSHSILGL
S586‑p GNPIAHIsPHRLLAR
S598‑p LARKNMVstKIQDTK
T599‑p ARKNMVstKIQDTKG
S737‑p KLVTPEGsPVRGLRT
  rat

 
Y28 QRLGGGTYGEVFKAR
T165 ISAQIGATLARRLSF
S171 ATLARRLSFIGTPYW
T175 RRLSFIGTPYWMAPE
Y177 LSFIGTPYWMAPEVA
N258 VKVTLTKNSKKRPSA
S319 AIPRRIRSTYRASSL
A323 RIRSTYRASSLGIPD
S324 IRSTYRASSLGIPDA
S325 RSTYRASSLGIPDAD
C348 QRPRCVECRSQADTV
T354 ECRSQADTVLLQPSA
S365 QPSADFRSTSPRSQL
T366 PSADFRSTSPRSQLS
S367 SADFRSTSPRSQLSD
S370 FRSTSPRSQLSDSDD
S373 TSPRSQLSDSDDDYD
S375 PRSQLSDSDDDYDDV
- gap
Y379 LSDSDDDYDDVDIPA
S403 PPKPKIRSPSDDGSG
S405 KPKIRSPSDDGSGGV
G411 PSDDGSGGVRDDGQL
S419‑p VRDDGQLsPGVLVRC
S428 GVLVRCASGPPPRIP
I434 ASGPPPRIPRPGPPP
A442 PRPGPPPATRSPHLT
R444 PGPPPATRSPHLTAR
S445 GPPPATRSPHLTARs
T449 ATRSPHLTARsDPSL
S452‑p SPHLTARsDPSLWNP
H567 SLSGKTPHLYSHSIL
Y569 SGKTPHLYSHSILGL
S592 GSPIAHISPHRFLAR
S604 LARKNMVSSKIQDTK
S605 ARKNMVSSKIQDTKG
A743 KLVTPEGAPAPGLRT
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