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BNIP3L
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope |
| Chromosomal Location of Human Ortholog: 8p21.2 |
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Cellular Component: endoplasmic reticulum; intrinsic to membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear speck
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Molecular Function: identical protein binding; lamin binding; protein binding; protein heterodimerization activity; protein homodimerization activity
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Biological Process: defense response to virus; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of macroautophagy; regulation of apoptosis
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Reference #:
O60238
(UniProtKB)
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Alt. Names/Synonyms: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNI3L; BNIP3A; BNIP3H; BNIP3L; NIP3-like protein X; NIP3L; NIX
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Gene Symbols: BNIP3L
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Molecular weight:
23,930 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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