|
BNIP3L
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
|
| Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope |
| Chromosomal Location of Human Ortholog: 14 D1|14 34.6 cM |
|
Cellular Component: cytosol; endoplasmic reticulum; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear speck
|
|
Molecular Function: identical protein binding; lamin binding; protein binding; protein heterodimerization activity; protein homodimerization activity
|
|
Biological Process: defense response to virus; negative regulation of apoptosis; negative regulation of programmed cell death; positive regulation of apoptosis; positive regulation of macroautophagy
|
|
Reference #:
Q9Z2F7
(UniProtKB)
|
|
Alt. Names/Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa-interacting protein 3-like; BCL2/adenovirus E1B 19kDa-interacting protein 3-like; BCL2/adenovirus E1B interacting protein 3-like; BNI3L; Bnip3l; C86132; D14Ertd719e; NIP3-like protein X; NIP3L; Nix; OTTMUSP00000027961
|
|
Gene Symbols: Bnip3l
|
|
Molecular weight:
23,766 Da
|
|
Basal Isoelectric point:
5.53
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
