|
BNIP3
Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Mitochondrial |
| Chromosomal Location of Human Ortholog: 10q26.3 |
|
Cellular Component: cytoplasm; dendrite; endoplasmic reticulum; integral to mitochondrial outer membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus
|
|
Molecular Function: GTPase binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity
|
|
Biological Process: apoptosis; cell death; defense response to virus; induction of apoptosis by granzyme; mitochondrial fragmentation during apoptosis; negative regulation of apoptosis; negative regulation of membrane potential; neuron apoptosis; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of macroautophagy; positive regulation of programmed cell death; positive regulation of protein complex disassembly; regulation of mitochondrial membrane permeability; response to hypoxia
|
|
Reference #:
Q12983
(UniProtKB)
|
|
Alt. Names/Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3; BNIP3; NIP3
|
|
Gene Symbols: BNIP3
|
|
Molecular weight:
27,832 Da
|
|
Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
