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Protein Page:
ARG1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARG1 Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC 3.5.3.1; Hydrolase
Cellular Component: cell soma; cytoplasm; extracellular space; mitochondrial outer membrane; neuron projection; nucleus
Molecular Function: arginase activity; manganese ion binding
Biological Process: arginine catabolic process to ornithine; arginine metabolic process; collagen biosynthetic process; positive regulation of endothelial cell proliferation; urea cycle
Reference #:  Q61176 (UniProtKB)
Alt. Names/Synonyms: AI; AI256583; Arg-1; Arg1; ARGI1; arginase 1, liver; arginase I; arginase, liver; Arginase-1; Liver-type arginase; PGIF; Type I arginase
Gene Symbols: Arg1
Molecular weight: 34,808 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ARG1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 K6‑ac __MSSKPksLEIIGA
0 1 K6‑ub __MSSKPksLEIIGA
0 3 S7‑p _MSSKPksLEIIGAP
0 2 S16 EIIGAPFSkGQPRGG
0 3 K17‑ac IIGAPFSkGQPRGGV
0 1 K17‑ub IIGAPFSkGQPRGGV
0 1 K17‑sc IIGAPFSkGQPRGGV
0 2 K26‑ub QPRGGVEkGPAALRK
0 5 K26‑ac QPRGGVEkGPAALRK
0 1 A29 GGVEkGPAALRKAGL
0 2 K39‑ac RKAGLLEkLkETEYD
0 1 K39‑ub RKAGLLEkLkETEYD
0 4 K41‑ac AGLLEkLkETEYDVR
0 1 K41‑ub AGLLEkLkETEYDVR
0 1 K41‑sc AGLLEkLkETEYDVR
0 84 H50 TEYDVRDHGDLAFVD
0 3 S62 FVDVPNDSSFQIVkN
0 2 K68‑ac DSSFQIVkNPRsVGk
0 1 K68‑ub DSSFQIVkNPRsVGk
0 3 S72‑p QIVkNPRsVGkANEE
0 1 K75 kNPRsVGKANEELAG
0 1 K75‑ub kNPRsVGkANEELAG
0 1 K75‑sc kNPRsVGkANEELAG
0 2 K89‑ac GVVAEVQkNGRVSVV
0 1 K89‑ub GVVAEVQkNGRVSVV
0 1 S94 VQkNGRVSVVLGGDH
0 1 S102 VVLGGDHSLAVGSIS
0 1 S107 DHSLAVGSISGHARV
0 1 S109 SLAVGSISGHARVHP
0 1 K153‑ub SFLLKELkGkFPDVP
0 1 K155‑ac LLKELkGkFPDVPGF
0 1 K155‑ub LLKELkGkFPDVPGF
0 17 S163‑p FPDVPGFsWVTPCIS
0 2 T166 VPGFsWVTPCISAKD
0 1 S170 sWVTPCISAKDIVYI
0 4 K191‑ac PGEHYIIkTLGIkYF
0 1 K191‑ub PGEHYIIkTLGIkYF
0 1 K191‑sc PGEHYIIkTLGIkYF
0 2 K196‑ac IIkTLGIkYFSMTEV
0 1 K196‑ub IIkTLGIkYFSMTEV
0 2 K205‑ac FSMTEVDkLGIGKVM
0 2 K205‑ub FSMTEVDkLGIGKVM
0 4 S217‑p KVMEETFsYLLGRKK
0 2 S230‑p KKRPIHLsFDVDGLD
0 1 T241‑p DGLDPAFtPATGTPV
0 2 Y265‑p LYITEEIyKTGLLSG
0 9 T281‑p DIMEVNPtLGkTAEE
0 3 K284‑ac EVNPtLGkTAEEVKS
0 1 K284‑ub EVNPtLGkTAEEVKS
0 1 K313‑ub TQREGNHkPGTDYLk
0 3 K320‑ac kPGTDYLkPPK____
  human

 
R6 __MSAKSRTIGIIGA
R6 __MSAKSRTIGIIGA
T7 _MSAKSRTIGIIGAP
S16‑p GIIGAPFsKGQPRGG
K17 IIGAPFsKGQPRGGV
K17 IIGAPFsKGQPRGGV
K17 IIGAPFsKGQPRGGV
E26 QPRGGVEEGPtVLRK
E26 QPRGGVEEGPtVLRK
T29‑p GGVEEGPtVLRKAGL
K39 RKAGLLEKLKEQECD
K39 RKAGLLEKLKEQECD
K41 AGLLEKLKEQECDVK
K41 AGLLEKLKEQECDVK
K41 AGLLEKLKEQECDVK
Y50‑p QECDVKDyGDLPFAD
S62‑p FADIPNDsPFQIVKN
K68 DsPFQIVKNPRsVGK
K68 DsPFQIVKNPRsVGK
S72‑p QIVKNPRsVGKASEQ
K75 KNPRsVGKASEQLAG
K75 KNPRsVGKASEQLAG
K75 KNPRsVGKASEQLAG
K89 GKVAEVKKNGRIsLV
K89 GKVAEVKKNGRIsLV
S94‑p VKKNGRIsLVLGGDH
S102‑p LVLGGDHsLAIGsIs
S107‑p DHsLAIGsIsGHARV
S109‑p sLAIGsIsGHARVHP
K153 SFLLKELKGKIPDVP
K155 LLKELKGKIPDVPGF
K155 LLKELKGKIPDVPGF
S163‑p IPDVPGFsWVtPCIs
T166‑p VPGFsWVtPCIsAKD
S170‑p sWVtPCIsAKDIVYI
K191‑ac PGEHYILkTLGIKYF
K191 PGEHYILKTLGIKYF
K191 PGEHYILKTLGIKYF
K196 ILkTLGIKYFSMTEV
K196 ILkTLGIKYFSMTEV
R205 FSMTEVDRLGIGKVM
R205 FSMTEVDRLGIGKVM
S217‑p KVMEETLsYLLGRKK
S230 KKRPIHLSFDVDGLD
T241 DGLDPSFTPATGTPV
Y265‑p LYITEEIyKTGLLSG
S281 DIMEVNPSLGKTPEE
K284 EVNPSLGKTPEEVTR
K284 EVNPSLGKTPEEVTR
K313 LAREGNHKPIDYLNP
N319 HKPIDYLNPPK____
  rat

 
K6‑ac __MSSKPkPIEIIGA
K6 __MSSKPKPIEIIGA
P7 _MSSKPkPIEIIGAP
S16 EIIGAPFSKGQPRGG
K17 IIGAPFSKGQPRGGV
K17 IIGAPFSKGQPRGGV
K17 IIGAPFSKGQPRGGV
K26 QPRGGVEKGPAALRK
K26‑ac QPRGGVEkGPAALRK
A29 GGVEkGPAALRKAGL
K39‑ac RKAGLVEkLkETEYN
K39 RKAGLVEKLkETEYN
K41‑ac AGLVEkLkETEYNVR
K41 AGLVEkLKETEYNVR
K41 AGLVEkLKETEYNVR
H50 TEYNVRDHGDLAFVD
S62‑p FVDVPNDsPFQIVkN
K68‑ac DsPFQIVkNPRSVGk
K68 DsPFQIVKNPRSVGk
S72 QIVkNPRSVGkANEQ
K75‑ac kNPRSVGkANEQLAA
K75 kNPRSVGKANEQLAA
K75 kNPRSVGKANEQLAA
K89 AVVAETQKNGTISVV
K89 AVVAETQKNGTISVV
S94 TQKNGTISVVLGGDH
S102 VVLGGDHSMAIGSIS
S107 DHSMAIGSISGHARV
S109 SMAIGSISGHARVHP
K153 AFLLKELKGKFPDVP
K155 LLKELKGKFPDVPGF
K155 LLKELKGKFPDVPGF
S163‑p FPDVPGFsWVTPCIS
T166 VPGFsWVTPCISAKD
S170 sWVTPCISAKDIVYI
K191‑ac PGEHYIIkTLGIkYF
K191 PGEHYIIKTLGIkYF
K191 PGEHYIIKTLGIkYF
K196‑ac IIkTLGIkYFSMTEV
K196 IIkTLGIKYFSMTEV
K205‑ac FSMTEVDkLGIGKVM
K205 FSMTEVDKLGIGKVM
S217‑p KVMEETFsYLLGRKK
S230 KKRPIHLSFDVDGLD
T241 DGLDPVFTPATGTPV
Y265 LYITEEIYKTGLLSG
T281‑p DIMEVNPtLGkTPEE
K284‑ac EVNPtLGkTPEEVTR
K284 EVNPtLGKTPEEVTR
K313 TKREGNHKPETDYLK
K320 KPETDYLKPPK____
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