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Protein Page:
AT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AT2 Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: Xq22-q23
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: angiotensin type II receptor activity; protein binding; receptor antagonist activity
Biological Process: blood vessel remodeling; cell surface receptor linked signal transduction; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cGMP nucleotide second messenger; negative regulation of cell growth; negative regulation of heart rate; negative regulation of nerve growth factor receptor signaling pathway; nitric oxide mediated signal transduction; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of vasodilation; regulation of blood pressure; regulation of systemic arterial blood pressure by circulatory renin-angiotensin
Reference #:  P50052 (UniProtKB)
Alt. Names/Synonyms: AGTR2; angiotensin II receptor, type 2; Angiotensin II type-2 receptor; AT2; ATGR2; MRX88; Type-2 angiotensin II receptor
Gene Symbols: AGTR2
Molecular weight: 41,184 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Select Structure to View Below

AT2

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S152 SVIYPFLSQRRNPWQ
0 1 K203‑ac IMAFPPEkYAQWSAG
0 1 S331‑p RFQQKLRsVFRVPIT
1 0 S348 QGKRESMSCRKSSSL
1 1 S354 MSCRKSSSLREMETF
  mouse

 
S152 SVIYPFLSQRRNPWQ
K203 IMAFPPEKYAQWSAG
S331 RFQQKLRSVFRVPIT
S348 QGKRETMSCRKGSsL
S354‑p MSCRKGSsLREMDTF
  rat

 
S152‑p SVIYPFLsQRRNPWQ
K203 IMAFPPEKYAQWSAG
S331 RFQQKLRSVFRVPIT
S348‑p QGKRETMsCRKSSsL
S354‑p MsCRKSSsLREMDTF
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